Journal ArticleDOI
Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.
Anastasia Detsi,Maya Majdalani,Christos Kontogiorgis,Dimitra Hadjipavlou-Litina,Panagiotis Kefalas +4 more
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TLDR
An extensive structure-relationship study was performed and revealed that several chalcones and aurones possess an appealing pharmacological profile combining high antioxidant and lipid peroxidation activity with potent soybean LOX inhibition.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2009-12-01. It has received 229 citations till now. The article focuses on the topics: Aureusidin.read more
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Anti-cancer chalcones: Structural and molecular target perspectives.
TL;DR: A comprehensive study on molecular targets/pathways involved in carcinogenesis, mechanism of actions (MOAs), structure activity relationships (SARs) and patents granted have been highlighted and may be helpful for (medicinal) chemists to design more potent, safe, selective and cost effective anti-cancer chalcones.
Journal ArticleDOI
Naturally occurring chalcones and their biological activities
Zsuzsanna Rozmer,Pál Perjési +1 more
TL;DR: The aim of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants to initiate further pharmacobotanical, biotechnological and medicinal studies on the field of chal cone research.
Journal ArticleDOI
Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.
TL;DR: The compounds which showed promising activity and have a well-defined MOAs, SARs must be considered as prototype for the design and development of potential anti-diabetic agents to meet the demand of diabetics.
Journal ArticleDOI
A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives
Karam Chand,Rajeshwari,Asha Hiremathad,Mahak Singh,M. Amélia Santos,Rangappa S. Keri,Rangappa S. Keri +6 more
TL;DR: This study systematically provides a comprehensive report on current developments in benzofuran-based compounds as antioxidant agents and is helpful for the researchers working on a substitution pattern around the nucleus, with an aim to help medicinal chemists to develop structure activity relationships (SAR) on these derivatives as antioxidant drugs.
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Chemical Constituents from the Rhizomes of Smilax glabra and Their Antimicrobial Activity
TL;DR: The results indicated that these antimicrobial constituents of this crude drug might be responsible for its clinical antimicrobial effect.
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
A review of anti-infective and anti-inflammatory chalcones.
TL;DR: This review is complementary to earlier reviews and covers more recent reports of antimicrobial activity of chalcones (antibacterial and antifungal), as well as antileishmanial, antimalarial, antiviral and anti-inflammatory activities of these compounds.
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Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Jan F. Stevens,Jonathan E. Page +1 more
TL;DR: Biological activities suggest that prenylflavonoids from hops have potential for application in cancer prevention programs and in prevention or treatment of (post-)menopausal 'hot flashes' and osteoporosis.
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Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents.
TL;DR: Several linear and angular coumarins designed and synthesised as possible anti-inflammatory and antioxidant agents were evaluated for their biological activities, using the carrageenin-induced rat paw oedema model and in general, the compounds were found to be potent anti- inflammatory agents.
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Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity.
TL;DR: The results suggest that in vivo, where lipid hydroperoxides are maintained at low steady-state levels, reduction of lipoxygenase from the ferric to ferrous state may be important in the regulation of lip Oxygenase activity and hence leukotriene biosynthesis.