Journal ArticleDOI
Natural products to prevent drug resistance in cancer chemotherapy: a review
TLDR
A concise review of two strategies using natural products against drug resistance, including nonapoptotic cell death and drug‐efflux inhibition, are summarized.Abstract:
Chemotherapy is the standard internal medical treatment for cancer. However, the resistance of cancer cells to nearly all kinds of chemotherapeutic drugs and targeted drugs has become prevalent, and approximately 80-90% of deaths in cancer patients are directly or indirectly attributed to drug resistance. The progress of new drug research and development has also been impeded by the occurrence of drug resistance, which has emerged as a considerable challenge in cancer therapy. Fortunately, natural products with diverse chemical structures and pharmacological effects serve as effective substances against drug resistance. Since the discovery of a series of drug-resistant proteins, drug-efflux inhibition has been applied as the primary strategy to overcome drug resistance by maintaining the intracellular concentrations of chemotherapeutic drugs. Nonapoptotic cell death is considered an alternative strategy because most cases of drug resistance result in evasion and insensitivity to apoptosis. In this concise review, we summarize two strategies using natural products against drug resistance.read more
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Natural compounds as potential adjuvants to cancer therapy: preclinical evidence
Shian-Ren Lin,Chia Hsiang Chang,Che Fang Hsu,May Jwan Tsai,Henrich Cheng,Max K. Leong,Ping-Jyun Sung,Jian Chyi Chen,Ching-Feng Weng +8 more
TL;DR: Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions.
Journal ArticleDOI
The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy.
TL;DR: It is hoped that this review will help to better understand the role of erastin in ferroptosis and lay the foundation for further research and the development of erstin-based cancer therapies in the future.
Progress and promise.
TL;DR: It required the rare combination of scientific authority, untiring energy, wise judgment, and business aptitude to construct a platform on which investigators of the many and diverse fields of natural knowledge could put their trust, and from which descriptions of their work would command attention.
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Molecular targets of curcumin in breast cancer (Review).
TL;DR: The chemistry and bioavailability of curcumin and its molecular targets in breast cancer are discussed and future research directions are discussed to further understand this promising natural product.
Journal ArticleDOI
Current scenario of indole derivatives with potential anti-drug-resistant cancer activity.
TL;DR: This review focuses on the recent development of indole derivatives with potential therapeutic application for drug-resistant cancers, and the mechanisms of action, the critical aspects of design as well as structure-activity relationships, covering articles published from 2010 to 2020.
References
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