New Insights into How the Rho Guanine Nucleotide Dissociation Inhibitor Regulates the Interaction of Cdc42 with Membranes
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A new model is proposed for how RhoGDI influences the ability of Cdc42 to move between membranes and the cytosol, which highlights the role of the membrane in helping Rho ganine nucleotide dissociation inhibitor to distinguish between the GDP- and GTP-bound forms of CDC42.About:
This article is published in Journal of Biological Chemistry.The article was published on 2009-08-28 and is currently open access. It has received 101 citations till now. The article focuses on the topics: RHO protein GDP dissociation inhibitor & Guanosine nucleotide dissociation inhibitors.read more
Citations
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Regulating Rho GTPases and their regulators
Richard G. Hodge,Anne J. Ridley +1 more
TL;DR: It has become apparent that Rho GTPases are regulated by post-translational modifications and the formation of specific protein complexes, in addition to GTP–GDP cycling.
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The 'invisible hand': regulation of RHO GTPases by RHOGDIs.
TL;DR: The invisible hand can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the R HO GTPase cycle.
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Cell Polarization and Cytokinesis in Budding Yeast
Erfei Bi,Hay-Oak Park +1 more
TL;DR: This chapter discusses the mechanics and spatial control of polarity development and cytokinesis, emphasizing the key concepts, mechanisms, and emerging questions in the field.
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Negative Feedback Enhances Robustness in the Yeast Polarity Establishment Circuit
TL;DR: The transient coexistence of multiple clusters during polarity establishment is shown using imaging with improved spatiotemporal resolution and it is found that initial polarity factor clustering is oscillatory, revealing the presence of a negative feedback loop that disperses the factors.
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Morphogenesis and the Cell Cycle
Audrey S. Howell,Daniel J. Lew +1 more
TL;DR: Defects in morphogenesis provide signals that feed back on the cyclin-CDK system, and what is known regarding regulation of cell-cycle progression in response to such defects is reviewed.
References
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Rho GTPases and the Actin Cytoskeleton
TL;DR: Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
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Rho GTPases: Biochemistry and Biology
Aron B. Jaffe,Alan Hall +1 more
TL;DR: This review presents the best characterized of these biochemical pathways that control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division.
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Rho and Rac Take Center Stage
TL;DR: This work will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins.
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The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
Omar A. Coso,Mario Chiariello,Jin-Chen Yu,Hidemi Teramoto,Piero Crespo,Ningzhi Xu,Toru Miki,J. Silvio Gutkind +7 more
TL;DR: It is shown that in COS-7 cells, activated Ras effectively stimulates MAPK but poorly induces JNK activity, which strongly support a critical role for Rac1 and Cdc42 in controlling the JNK signaling pathway.