New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification.
TLDR
The current and future PPGL classifications are reviewed, with a focus on hereditary syndromes, and the current strengths and shortcomings of precision medicine are discussed.Abstract:
A molecular biology–based taxonomy has been proposed for pheochromocytoma and paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant prognostic and predictive biomarkers and stratified PPGLs into three main clusters. Each subgroup has a distinct molecular–biochemical–imaging signature. Concurrently, new methods for biochemical analysis, functional imaging, and medical therapies have also become available. The research community now strives to match the cluster biomarkers with the best intervention. The concept of precision medicine has been long awaited and holds great promise for improved care. Here, we review the current and future PPGL classifications, with a focus on hereditary syndromes. We discuss the current strengths and shortcomings of precision medicine and suggest a condensed manual for diagnosis and treatment of both adult and pediatric patients with PPGL. Finally, we consider the future direction of this field, with a particular focus on how advanced molecular characterization of PPGL can improve a patient’s outcome, including cures and, ultimately, disease prevention.read more
Citations
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European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma.
David Taïeb,Rodney J. Hicks,Elif Hindié,Benjamin Guillet,Anca M. Avram,Pietro Ghedini,Henri J L M Timmers,Aaron T. Scott,Saeed Elojeimy,Domenico Rubello,Irene Virgolini,Stefano Fanti,Sona Balogova,Neeta Pandit-Taskar,Karel Pacak +14 more
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The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2
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Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension.
Jacques W.M. Lenders,Jacques W.M. Lenders,Michiel N. Kerstens,Laurence Amar,Aleksander Prejbisz,Mercedes Robledo,David Taïeb,Karel Pacak,Joakim Crona,Tomáš Zelinka,Massimo Mannelli,Timo Deutschbein,Henri J L M Timmers,Frederic Castinetti,Henning Dralle,Jřri Widimský,Anne-Paule Gimenez-Roqueplo,Graeme Eisenhofer +17 more
TL;DR: The relevant genetic causes of PPGLs are addressed and how genetic testing can be incorporated within clinical care is outlined, and risk factors for developing metastatic disease and how they may facilitate personalised follow-up are discussed.
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Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up†
Martin Fassnacht,Guillaume Assié,Eric Baudin,Graeme Eisenhofer,C. de la Fouchardiere,Harm R. Haak,Harm R. Haak,R. R. de Krijger,Francesco Porpiglia,Massimo Terzolo,Alfredo Berruti +10 more
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Current Management of Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician in the Era of Precision Medicine.
Svenja Nölting,Martin Ullrich,Jens Pietzsch,Jens Pietzsch,Christian G. Ziegler,Graeme Eisenhofer,Ashley B. Grossman,Karel Pacak +7 more
TL;DR: This review provides a guide for practicing clinicians summarizing current management of PCC/PGL according to tumor size, location, age of first diagnosis, presence of metastases, and especially underlying mutations in the era of precision medicine.
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