Journal ArticleDOI
NF-kappaB in mammary gland development and breast cancer.
Yixue Cao,Michael Karin +1 more
TLDR
This article showed that NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues and there are strong suggestions that NF plays an important role in the etiology of breast cancer.Abstract:
Nuclear factor of kappaB (NF-kappaB) is a group of sequence-specific transcription factors that is best known as a key regulator of the inflammatory and innate immune responses. Recent studies of genetically engineered mice have clearly indicated that NF-kappaB is also required for proper organogenesis of several epithelial tissues, including the mammary gland. Mice have shown severe lactation deficiency when NF-kappaB activation is specifically blocked in the mammary gland. In addition, there are strong suggestions that NF-kappaB may play an important role in the etiology of breast cancer. Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues.read more
Citations
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Inflammation meets cancer, with NF-κB as the matchmaker
Yinon Ben-Neriah,Michael Karin +1 more
TL;DR: Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors.
Journal ArticleDOI
Breast Cancer Growth Prevention by Statins
Michael J. Campbell,Laura J. Esserman,Yamei Zhou,Mark Shoemaker,Margaret Lobo,Elizabeth Borman,Frederick L. Baehner,Anjali S. Kumar,Kelly Adduci,Corina Marx,Emanuel F. Petricoin,Lance A. Liotta,Mary Winters,Stephen C. Benz,Christopher C. Benz +14 more
TL;DR: In vivo results showed that oral dosing of statins significantly inhibited the growth of a mouse mammary carcinoma, and supporting rationale for future statin trials in breast cancer patients is provided.
Journal ArticleDOI
Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies
Peeter Karihtala,Ylermi Soini +1 more
TL;DR: The present review aims to clarify the significance of oxidative stress and the role of cell redox state modulating systems in human malignancies in light of the current literature.
Journal ArticleDOI
Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers.
Michèle Sabbah,Shahin Emami,Gérard Redeuilh,Sylvia Julien,Gregoire Prevost,Amazia Zimber,Radia Ouelaa,Marc Bracke,Olivier De Wever,Olivier De Wever,Christian Gespach +10 more
TL;DR: Identification of the factors that initiate, modulate and effectuate EMT signatures and their underlying upstream oncogenic pathways should provide the basis of more efficient strategies to fight cancer progression as well as genetic and epigenetic forms of drug resistance.
Journal ArticleDOI
Functions of CXCL12 and CXCR4 in breast cancer.
Kathryn E. Luker,Gary D. Luker +1 more
TL;DR: This review focuses on functions of CXCR4 and CXCL12 in primary and metastatic breast cancer, including molecular mechanisms of action and relationships of this pathway to other key regulators of breast cancer progression.
References
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Journal ArticleDOI
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Michael Karin,Yinon Ben-Neriah +1 more
TL;DR: Recent progress has been made in understanding the details of the signaling pathways that regulate NF-kappaB activity, particularly those responding to the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1.
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Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI
Missing Pieces in the NF-κB Puzzle
Sankar Ghosh,Michael Karin +1 more
TL;DR: In this paper, a review of recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK is presented, focusing on recent progress and unanswered questions.
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NF-κB at the crossroads of life and death
Michael Karin,Anning Lin +1 more
TL;DR: The choice between life and death is one of the major events in regulation of the immune system and a major regulator of such life or death decisions is the transcription factor NF-κB as mentioned in this paper.
Journal ArticleDOI
NF-κB in cancer: from innocent bystander to major culprit
TL;DR: Recent evidence indicates that NF-κB and the signalling pathways that are involved in its activation are also important for tumour development.