Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures
Patrick H.N. Celie,Sarah E. van Rossum-Fikkert,Willem J. van Dijk,Katjuša Brejc,August B. Smit,Titia K. Sixma +5 more
TLDR
Atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABAA,GABAC, 5HT3 serotonin, and glycine receptors are presented.About:
This article is published in Neuron.The article was published on 2004-03-25 and is currently open access. It has received 771 citations till now. The article focuses on the topics: Cys-loop receptors & Acetylcholine binding.read more
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Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution
TL;DR: A comparison of the structure of the alpha subunit with that of AChBP having ligand present, suggests how the localised rearrangement overcomes the distortions and initiates the rotational movements associated with opening of the channel.
Journal ArticleDOI
Mammalian nicotinic acetylcholine receptors: from structure to function.
TL;DR: This review provides a comprehensive overview of the advancement of functional and genetic studies in the late 1980s and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more
TL;DR: The neonicotinoids have outstanding potency and systemic action for crop protection against piercing-sucking pests, and they are highly effective for flea control on cats and dogs.
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Aromatic rings in chemical and biological recognition: energetics and structures.
TL;DR: This review describes a multidimensional treatment of molecular recognition phenomena involving aromatic rings in chemical and biological systems that facilitates the development of new advanced materials and supramolecular systems, and should inspire further utilization of interactions with aromatic rings to control the stereochemical outcome of synthetic transformations.
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A Medicinal Chemist’s Guide to Molecular Interactions
TL;DR: This article compile and review the literature on molecular interactions as it pertains to medicinal chemistry through a combination of careful statistical analysis of the large body of publicly available X-ray structure data and experimental and theoretical studies of specific model systems.
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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.
Katjuša Brejc,W.J. van Dijk,Remco V. Klaassen,M. Schuurmans,J. van der Oost,J. van der Oost,August B. Smit,Titia K. Sixma +7 more
TL;DR: The crystal structure of molluscan acetylcholine-binding protein (AChBP), a structural and functional homologue of the amino-terminal ligand-binding domain of an nAChR α-subunit, is presented and is relevant for the development of drugs against Alzheimer’s disease and nicotine addiction.