Journal ArticleDOI
NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus.
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This article is published in European Journal of Pharmacology.The article was published on 1990-10-23. It has received 223 citations till now. The article focuses on the topics: Nucleus accumbens & Dopamine.read more
Citations
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A neuropsychological theory of positive affect and its influence on cognition.
TL;DR: A new neuropsychological theory is proposed that accounts for many of the effects of positive affect on olfaction, the consolidation of long-term memories, working memory, and creative problem solving by assuming that positive affect is associated with increased brain dopamine levels.
Journal ArticleDOI
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
TL;DR: The generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit is reported, supporting a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype.
Journal ArticleDOI
Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement
TL;DR: Identifying the neurotransmitter content and projection target of VTA neurons recorded in vivo will be critical for determining their contribution to learned appetitive behaviors.
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Chronic ethanol consumption:from neuroadaptation to neurodegeneration
Fabio Fadda,Zvani L. Rossetti +1 more
TL;DR: Evidence suggests a link between the neuroadaptive mechanisms underlying the development of ethanol dependence and those underlying the functional and structural alterations induced by chronic ethanol.
Journal ArticleDOI
Pharmacology and behavioral pharmacology of the mesocortical dopamine system
TL;DR: The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex behavioral responses and the findings concerning the function or role of the mPFC are relatively inconsistent, the question is addressed whether these inconsistencies might be related to the anatomical and functional heterogeneity of this brain area.
References
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Journal ArticleDOI
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Erik H. F. Wong,John A. Kemp,Tony Priestley,Antony R. Knight,Geoffrey Neil Woodruff,L. L. Iversen +5 more
TL;DR: Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrated a potent, selective, and noncompetitive antagonistic action of MK-801 on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate, providing an explanation for the mechanism of action ofMK-801 as an anticonvulsant.
Journal ArticleDOI
Dopamine release in the nucleus caudatus and in the nucleus accumbens is under glutamatergic control through non-NMDA receptors: a study in freely-moving rats.
TL;DR: The results indicate that the dopaminergic system, within the caudate and the accumbens nuclei, is under glutamatergic control through kainate and quisqualate receptors, while the NMDA receptors do not appear to be involved.
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Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.
B.A. Donzanti,Norman J. Uretsky +1 more
TL;DR: The results suggest that receptors in the nucleus accumbens, sensitive to kainic and quisqualic acids, play a more important role in the stimulation of locomotor activity than those sensitive to N-methyl-DL-aspartic acid.
Journal ArticleDOI
Synthesis and NMD A Antagonistic Properties of the Enantiomers of 4‐(3‐phosphonopropyl)piperazine‐2‐carboxylic acid (CPP) and of the unsaturated analogue (E)‐4‐(3‐phosphonoprop‐2‐enyl)piperazine‐2‐carboxylic acid (CPP‐ene)
Bernard Aebischer,Peter Frey,Hans-Peter Haerter,Paul L. Herrling,Werner Dr Mueller,Henry J. Olverman,Jeffrey C. Watkins +6 more
TL;DR: D-CPP-ene appears to be the most potent, enantiomerically pure, competitive NMDA antagonist known to date.
Journal ArticleDOI
Behavioural effects of N-methyl-D-aspartate in the anterodorsal striatum of the rat.
W.J. Schmidt,D. Bury +1 more
TL;DR: N-methyl-D-aspartate (NMDA) bilaterally injected into the anterodorsal striatum of rats reduced locomotion, sniffing, rearing and feeding upon presentation of palatable food, and the number of all behavioural bouts exhibited was reduced and the duration of akinetic phases was prolonged.
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The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice
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