Journal ArticleDOI
Non-heme iron nitrosyls in biology
Anthony R. Butler,Ian L. Megson +1 more
About:
This article is published in Chemical Reviews.The article was published on 2002-03-12. It has received 320 citations till now.read more
Citations
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Copper complexes as anticancer agents
TL;DR: This overview, collecting the most significant strategies adopted in the last ten years to design promising anticancer copper(I,II) compounds, would be a help to the researchers working in this field.
Journal ArticleDOI
Recent developments in nitric oxide donor drugs
Mark R. Miller,Ian L. Megson +1 more
TL;DR: This review explores some of the most promising recent advances in NO donor drug development and addresses the challenges associated with NO as a therapeutic agent.
Journal ArticleDOI
What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology.
TL;DR: This minireview emphasizes the current understanding of the biochemistry of NO and place it in a biological context and highlights a growing importance of the secondary metabolites of NO-dependent reactions in the post-translational modification of key metabolic and signaling proteins.
Journal ArticleDOI
Photoactive Ruthenium Nitrosyls: Effects of Light and Potential Application as NO Donors.
TL;DR: Although some ruthenium nitrosyls are stable under physiological conditions and are capable to NO delivery to proteins such as myoglobin and cytochrome c oxidase, so far success has been limited in using these nitroSyls as light-activated NO donors in cellular and tissue models.
References
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Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
Journal ArticleDOI
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
Guy C. Brown,Chris E. Cooper +1 more
TL;DR: Nitric oxide reversibly inhibited oxygen consumption of brain synaptosomes and was apparently competitive with oxygen, suggesting that NO inhibition of cytochrome oxidase and the competion with oxygen may occur in vivo.
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Guanylate cyclase and the ⋅NO/cGMP signaling pathway
TL;DR: This review will focus on the role of sGC in signaling, its relationship to the other nucleotide cyclases, and on what is known about sGC genetics, heme environment and catalysis.
Journal ArticleDOI
Inhibition of Mitochondrial Electron Transport by Peroxynitrite
TL;DR: It is reported that peroxynitrite exposure to rat heart mitochondria resulted in significant inactivation of electron carriers such as succinate dehydrogenase and NADH dehydrogenases as well as the mitochondrial ATPase, indicating that mitochondria may constitute a key intracellular loci for the toxic effects of peroxysitrite under the various pathological conditions in which each appears to play a contributory role.
Journal ArticleDOI
Nitric oxide and mitochondrial respiration.
TL;DR: In this article, it was shown that low (nanomolar) concentrations of NO specifically inhibit cytochrome oxidase in competition with oxygen, and this inhibition is fully reversible when NO is removed.