Journal ArticleDOI
Noncovalent interactions of bovine α-lactalbumin with green tea polyphenol, epigalocatechin-3-gallate
Ayah Al-Hanish,Dragana Stanic-Vucinic,Jelena Mihailovic,Ivana Prodic,Simeon Minic,Marija Stojadinovic,Milica Radibratovic,Miloš Milčić,Tanja Cirkovic Velickovic +8 more
TLDR
The docking analysis shows that EGCG binds in the hydrophobic pocket at the entrance of cleft between α-helical and β-sheet-rich domains and includes residues of aromatic cluster II and the isothermal titration calorimetry results suggest that the binding of E GCG to ALA is enthalpically favorable.About:
This article is published in Food Hydrocolloids.The article was published on 2016-12-01. It has received 103 citations till now. The article focuses on the topics: Isothermal titration calorimetry.read more
Citations
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Scientific opinion on the safety of green tea catechins
Maged Younes,Peter Aggett,Fernando Aguilar,Riccardo Crebelli,Birgit Dusemund,Metka Filipič,Maria Jose Frutos,Pierre Galtier,David Michael Gott,Ursula Gundert-Remy,Claude Lambré,Jean-Charles Leblanc,Inger Therese Lillegaard,Peter Moldeus,Alicja Mortensen,Agneta Oskarsson,Ivan Stankovic,Ine Waalkens-Berendsen,Rudolf Antonius Woutersen,Raul J Andrade,Cristina Fortes,Pasquale Mosesso,Patrizia Restani,Davide Arcella,Fabiola Pizzo,Camilla Smeraldi,Matthew Wright +26 more
TL;DR: There is evidence from interventional clinical trials that intake of doses equal or above 800 mg EGCG/day taken as a food supplement has been shown to induce a statistically significant increase of serum transaminases in treated subjects compared to control.
Journal ArticleDOI
Interactions between milk proteins and polyphenols: Binding mechanisms, related changes, and the future trends in the dairy industry
TL;DR: The conflicting results on the functionality of polyphenols interacting with milk proteins either in model systems or in complex dairy matrices reveal the need for future studies.
Journal ArticleDOI
A review of methods used for investigation of protein–phenolic compound interactions
TL;DR: The main aim of this review is to give researchers an overview of the currently used methods that can be applied to study the interactions between proteins and phenolic compounds.
Journal ArticleDOI
Interaction characterization of preheated soy protein isolate with cyanidin-3-O-glucoside and their effects on the stability of black soybean seed coat anthocyanins extracts.
Zhongqin Chen,Cong Wang,Xudong Gao,Yue Chen,Ramesh Kumar Santhanam,Chunli Wang,Leilei Xu,Haixia Chen +7 more
TL;DR: The results suggested that preheated soy protein isolate-cyanidin-3-O-glucoside interaction could effectively protect anthocyanins' stability through strong binding affinity influenced by the systematic alterations in the secondary structure.
Journal ArticleDOI
Effect of pH-shifting treatment on structural and functional properties of whey protein isolate and its interaction with (−)-epigallocatechin-3-gallate
Weijun Chen,Wen-Jun Wang,Xiaobin Ma,Ruiling Lv,Ritesh Balaso Watharkar,Tian Ding,Xingqian Ye,Donghong Liu +7 more
TL;DR: It is confirmed that pH-shifting treatment can improve functional properties of whey protein isolate and its potential as a protective carrier for polyphones.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
Oleg Trott,Arthur J. Olson +1 more
TL;DR: AutoDock Vina achieves an approximately two orders of magnitude speed‐up compared with the molecular docking software previously developed in the lab, while also significantly improving the accuracy of the binding mode predictions, judging by tests on the training set used in AutoDock 4 development.
Journal ArticleDOI
CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
Bernard R. Brooks,Robert E. Bruccoleri,Barry D. Olafson,David J. States,S. Swaminathan,Martin Karplus +5 more
TL;DR: The CHARMM (Chemistry at Harvard Macromolecular Mechanics) as discussed by the authors is a computer program that uses empirical energy functions to model macromolescular systems, and it can read or model build structures, energy minimize them by first- or second-derivative techniques, perform a normal mode or molecular dynamics simulation, and analyze the structural, equilibrium, and dynamic properties determined in these calculations.
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H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations
TL;DR: The latest version of H++ includes several new capabilities and options: fix erroneous (flipped) side chain conformations for HIS, GLN and ASN, include a ligand in the input structure, process nucleic acid structures and generate a solvent box with specified number of common ions for explicit solvent MD.
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