Journal ArticleDOI
Novel self-assembled tacrolimus nanoparticles cross-linking thermosensitive hydrogels for local rheumatoid arthritis therapy
Wu Huimin,Kaiyuan Wang,Hanning Wang,Fang Chen,Wencong Huang,Yuqi Chen,Jiali Chen,Jin Tao,Xiaoguang Wen,Subin Xiong +9 more
TLDR
Soluplus-SNPs hydrogel is a potential sustainable delivery system for FK506 to treat RA locally and shows lower viscosity and wider range concentrations in sol state at 25°C and stronger gel strength at 37°C than P407.About:
This article is published in Colloids and Surfaces B: Biointerfaces.The article was published on 2017-01-01. It has received 35 citations till now. The article focuses on the topics: Self-healing hydrogels & Poloxamer 407.read more
Citations
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Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering
TL;DR: In this article, the authors presented a review of the use of biomimetic hydrogels in bone tissue engineering, and some key factors that can determine the therapy effect for bone tissue regeneration were also mentioned.
Journal ArticleDOI
Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering
TL;DR: In this article , the authors presented a review of the use of biomimetic hydrogels in bone tissue engineering, and some key factors that can determine the therapy effect for bone tissue regeneration were also mentioned.
Journal ArticleDOI
Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity.
TL;DR: This review highlights recent advances and novel techniques to enhance the delivery, localization, retention, and activity of these factors, providing an overview of the cartilage drug delivery field that can guide future research in restorative and regenerative treatments for damaged cartilage.
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Polymeric Hydrogels as Technology Platform for Drug Delivery Applications.
TL;DR: The present work overviews the most relevant and recent applications of hydrogels in drug delivery with special emphasis on mucosal routes.
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Micellisation Mechanism and Behaviour of Soluplus®⁻Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System.
TL;DR: Homogeneity in the estimated micellar size and morphology was shown for monophasic micelle dispersions in lower concentrations and with a shift towards more complex structures or aggregates in higher concentrations, and the implications for oral drug delivery are discussed.
References
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Journal ArticleDOI
A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics
TL;DR: New findings have demonstrated immuno-modulation and cytotoxicity-promoting properties of Poloxamer 407 revealing significant pharmacological interest and, hence, human trials are in progress to specify these potential applications.
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Encapsulation of hydrophobic drugs in Pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH.
TL;DR: Three drugs, ibuprofen, aspirin, and erythromycin, are encapsulated in spherical Pluronic F127 micelles and the mean hydrodynamic radii and polydispersities of the micells are found to increase with decrease in temperature and in the presence of drug molecules.
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Construction of Drug–Polymer Thermodynamic Phase Diagrams Using Flory–Huggins Interaction Theory: Identifying the Relevance of Temperature and Drug Weight Fraction to Phase Separation within Solid Dispersions
TL;DR: A novel method, based on Flory-Huggins theory, to predict and compare the solubility and miscibility of drug in polymeric systems is proposed and the maximum crystalline drug solubilty and amorphous drug miscibility may be predicted based on the phase diagrams.
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Experimental investigation and mathematical modeling of Pluronic F127 gel dissolution: drug release in stirred systems.
TL;DR: A predictive mathematical model based on the assumption that uptake of water into the gel and subsequent disentanglement of F127 micelles control gel dissolution is developed, and there is good agreement between experimental results and model predictions for stirring speeds above 20 rpm.
Journal ArticleDOI
Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles
Linghui Dian,Linghui Dian,Enjiang Yu,Xiaona Chen,Xinguo Wen,Zhang Zhengzan,Lingzhen Qin,Qingqing Wang,Ge Li,Chuanbin Wu +9 more
TL;DR: The pharmacokinetic study in beagle dogs showed that absorption of quercetin after oral administration of Qu-PMs was improved significantly, with a half-life 2.19-fold longer and a relative oral bioavailability of 286% as compared to free quercETin.