NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration.
TLDR
A gene, nudF, which is required for nuclear migration during vegetative growth as well as development is cloned, suggesting that the LIS-1 gene product may have a function similar to that of NUDF and supports previous findings to suggest that nuclear migration may play a role in neuronal migration.Abstract:
During a study of the genetics of nuclear migration in the filamentous fungus Aspergillus nidulans, we cloned a gene, nudF, which is required for nuclear migration during vegetative growth as well as development. The NUDF protein level is controlled by another protein NUDC, and extra copies of the nudF gene can suppress the nudC3 mutation. nudF encodes a protein with 42% sequence identity to the human LIS-1 (Miller-Dieker lissencephaly-1) gene, which is required for proper neuronal migration during brain development. This strong similarity suggests that the LIS-1 gene product may have a function similar to that of NUDF and supports previous findings to suggest that nuclear migration may play a role in neuronal migration.read more
Citations
More filters
Journal ArticleDOI
Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons.
TL;DR: It is demonstrated that DCX is expressed in migrating neurons throughout the central and peripheral nervous system during embryonic and postnatal development and likely directs neuronal migration by regulating the organization and stability of microtubules.
Journal ArticleDOI
Cell migration in the forebrain.
Oscar Marín,John L.R. Rubenstein +1 more
TL;DR: The cellular and molecular mechanisms underlying each of these types of migrations are reviewed and how emerging concepts in neuronal migration are reshaping the understanding of forebrain development in normal and pathological situations are discussed.
Journal ArticleDOI
Modes of neuronal migration in the developing cerebral cortex.
TL;DR: Evidence is reviewed for two modes of radial movement: somal translocation, which is adopted by the early-generated neurons; and glia-guided locomotion, which was used predominantly by pyramidal cells.
Journal ArticleDOI
Microtubule-based transport systems in neurons: the roles of kinesins and dyneins.
TL;DR: This review describes the current understanding of the functions of kinesins and dyneins and how these motor proteins may be harnessed to generate some of the unique properties of neuronal cells.
Journal ArticleDOI
Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
Shinji Hirotsune,Mark W. Fleck,Michael J. Gambello,Gregory J. Bix,Amy Chen,Gary D. Clark,David H. Ledbetter,Chris J. McBain,Anthony Wynshaw-Boris +8 more
TL;DR: An essential, dosage-sensitive neuronal-specific role for Pafah1b1 in neuronal migration throughout the brain, and an essential role in early embryonic development are demonstrated.