Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients.
Jerome R. Lechien,Pierre Cabaraux,Carlos M. Chiesa-Estomba,Mohamad Khalife,Stéphane Hans,Christian Calvo-Henriquez,Delphine Martiny,Delphine Martiny,Fabrice Journe,Leigh J. Sowerby,Sven Saussez,Sven Saussez +11 more
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TLDR
To investigate olfactory dysfunction in patients with mild coronavirus disease 2019 (COVID‐19) through patient‐reported outcome questionnaires and objective psychophysical testing.Abstract:
Objective: To investigate olfactory dysfunction (OD) in patients with mild coronavirus disease 2019 (COVID-19) through patient-reported outcome questionnaires and objective psychophysical testing. Methods: COVID-19 patients with self-reported sudden-onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sinonasal outcome-22. Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey. Objective OD was evaluated using psychophysical tests. Results: Eighty-six patients completed the study. The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%), and postnasal drip (48.6%). Total loss of smell was self-reported by 61.4% of patients. Objective olfactory testings identified 41 anosmic (47.7%), 12 hyposmic (14.0%), and 33 normosmic (38.3%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction or postnasal drip. Conclusion: A significant proportion of COVID-19 patients reporting OD do not have OD on objective testing.read more
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Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19).
TL;DR: In this article, a review of all current published literature (studies, case reports, case series, reviews, editorials, and other articles) was conducted and neurological sequelae of COVID-19 were summarized.
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Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study.
Luigi Angelo Vaira,Claire Hopkins,Marzia Petrocelli,Jerome R. Lechien,Carlos M. Chiesa-Estomba,Giovanni Salzano,Marco Cucurullo,Francesco Antonio Salzano,Sven Saussez,Paolo Boscolo-Rizzo,Federico Biglioli,G De Riu +11 more
TL;DR: Chemosensitive disturbances persisted in 7.2 per cent of patients 60 days after clinical onset and specific therapies should be initiated in patients with severe olfactory and gustatory disturbances 20 days after disease onset.
Journal ArticleDOI
Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients.
Jerome R. Lechien,Carlos M. Chiesa-Estomba,Eline Beckers,Vincent Mustin,Morgane Ducarme,Fabrice Journe,Arnaud Marchant,Lionel Jouffe,Maria Rosaria Barillari,Giovanni Cammaroto,Marta P. Circiu,Stéphane Hans,Sven Saussez,Sven Saussez +13 more
TL;DR: In this article, the authors investigated prevalence and recovery of olfactory dysfunction in COVID-19 patients according to the disease severity and found that the prevalence of OD was significantly higher in mild form (85.9%) compared with moderate-to-critical forms (4.5-6.9%).
Journal ArticleDOI
Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients.
TL;DR: A systematic review and meta‐analysis was conducted to estimate the overall pooled prevalence of olfactory dysfunction in COVID‐19 patients and found that it was higher in women than in men.
Journal ArticleDOI
Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19 positive patients compared to subjective methods: A systematic review and meta-analysis
Mackenzie E. Hannum,Vicente A Ramirez,Vicente A Ramirez,Sarah J Lipson,Riley D Herriman,Aurora K Toskala,Cailu Lin,Paule V. Joseph,Danielle R. Reed +8 more
TL;DR: Objective measures are a more sensitive method to identify smell loss as a result of infection with SARS-CoV-2; the use of subjective measures, while expedient during the early stages of the pandemic, underestimates the true prevalence of smell loss.
References
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Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.
Jerome R. Lechien,Carlos M. Chiesa-Estomba,Daniele R De Siati,Mihaela Horoi,Serge D Le Bon,Alexandra Rodriguez,Didier Dequanter,Serge Blecic,Fahd El Afia,Lea Distinguin,Younes Chekkoury-Idrissi,Stéphane Hans,Irene Lopez Delgado,Christian Calvo-Henriquez,Philippe Lavigne,Chiara Falanga,Maria Rosaria Barillari,Giovanni Cammaroto,Mohamad Khalife,Pierre Leich,Christel Souchay,Camelia Rossi,Fabrice Journe,Julien Hsieh,Myriam Edjlali,Myriam Edjlali,Robert Carlier,Laurence Ris,Andrea Lovato,Cosimo de Filippis,Frédérique Coppée,Nicolas Fakhry,Tareck Ayad,Sven Saussez +33 more
TL;DR: Olfactory and gustatory disorders are prevalent symptoms in European CO VID-19 patients, who may not have nasal symptoms, and the sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.
Journal ArticleDOI
The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients
TL;DR: It remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19, which emerged in December 2019 in Wuhan, China and rapidly spreads around the world.
Journal ArticleDOI
Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects.
TL;DR: The present data suggest specific changes of individual olfactory functions in relation to age, with odor thresholds declining most dramatically compared to odor discrimination and odor identification.
Journal ArticleDOI
Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.
TL;DR: The results show that neurons are a highly susceptible target for SARS-CoV and that only the absence of the host cell receptor prevents severe murine brain disease.
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Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20)
TL;DR: The psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20), a disease-specific, health-related quality-of-life measure for rhinosinusitis, was analyzed.
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