Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms.
Reads0
Chats0
TLDR
Understanding the timing and association of smell/taste loss in COVID‐19 may help facilitate screening and early isolation of cases.Abstract:
Background Rapid spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of coronavirus disease 2019 (COVID-19) infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell/taste loss in COVID-19 may help facilitate screening and early isolation of cases. Methods A single-institution, cross-sectional study evaluating patient-reported symptoms with a focus on smell and taste was conducted using an internet-based platform on adult subjects who underwent testing for COVID-19. Logistic regression was employed to identify symptoms associated with COVID-19 positivity. Results A total of 1480 patients with influenza-like symptoms underwent COVID-19 testing between March 3, 2020, and March 29, 2020. Our study captured 59 of 102 (58%) COVID-19-positive patients and 203 of 1378 (15%) COVID-19-negative patients. Smell and taste loss were reported in 68% (40/59) and 71% (42/59) of COVID-19-positive subjects, respectively, compared to 16% (33/203) and 17% (35/203) of COVID-19-negative patients (p Conclusion In ambulatory individuals with influenza-like symptoms, chemosensory dysfunction was strongly associated with COVID-19 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks, paralleling resolution of other disease-related symptoms.read more
Citations
More filters
Journal ArticleDOI
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.
David H. Brann,Tatsuya Tsukahara,Caleb Weinreb,Marcela Lipovsek,Koen Van den Berge,Koen Van den Berge,Boying Gong,Rebecca K. Chance,Iain C. Macaulay,Hsin-jung Chou,Russell B. Fletcher,Diya Das,Diya Das,Kelly Street,Hector Roux de Bézieux,Yoon Gi Choi,Davide Risso,Sandrine Dudoit,Elizabeth Purdom,Jonathan Mill,Ralph Abi Hachem,Hiroaki Matsunami,Darren W. Logan,Bradley J. Goldstein,Matthew S. Grubb,John Ngai,Sandeep Robert Datta +26 more
TL;DR: It is suggested that CoV-2 infection of non-neuronal cell types leads to anosmia and related disturbances in odor perception in COVID-19 patients.
Journal ArticleDOI
Smell dysfunction: a biomarker for COVID-19.
Shima T. Moein,Seyed Mohammadreza Hashemian,Babak Mansourafshar,Ali Khorram‐Tousi,Payam Tabarsi,Richard L. Doty +5 more
TL;DR: Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2), the virus that causes coronavirus disease 2019 (COVID‐19), is responsible for the largest pandemic since the 1918 influenza A virus subtype H1N1 influenza outbreak.
Journal ArticleDOI
The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis.
TL;DR: Olfactory and gustatory dysfunction are common symptoms in patients with COVID-19 and may represent early symptoms in the clinical course of infection and increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission.
Journal ArticleDOI
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease.
Thomas Struyf,Jonathan J Deeks,Jonathan J Deeks,Jacqueline Dinnes,Jacqueline Dinnes,Yemisi Takwoingi,Yemisi Takwoingi,Clare Davenport,Clare Davenport,Mariska M.G. Leeflang,René Spijker,René Spijker,Lotty Hooft,Devy Emperador,Sabine Dittrich,Julie Domen,Sebastiaan R A Horn,Ann Van den Bruel +17 more
TL;DR: The diagnostic accuracy of signs and symptoms is assessed to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID‐19 clinics, has CO VID‐19 disease or COVID19 pneumonia.
Journal ArticleDOI
Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement.
Oren K. Fix,Bilal Hameed,Robert J. Fontana,Ryan M. Kwok,Brendan M. McGuire,David C. Mulligan,Daniel S. Pratt,Mark W. Russo,Michael L. Schilsky,Elizabeth C. Verna,Rohit Loomba,David E. Cohen,Jorge A. Bezerra,K. Rajender Reddy,Raymond T. Chung +14 more
TL;DR: The aim is to provide a template for the development of clinical recommendations and policies to mitigate the impact of the COVID‐19 pandemic on liver patients and healthcare providers.
References
More filters
Journal ArticleDOI
Presumed Asymptomatic Carrier Transmission of COVID-19.
TL;DR: This study describes possible transmission of novel coronavirus disease 2019 (COVID-19) from an asymptomatic Wuhan resident to 5 family members in Anyang, a Chinese city in the neighboring province of Hubei.
Journal ArticleDOI
Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
TL;DR: The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.
Journal ArticleDOI
Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study.
Andrea Giacomelli,Laura Pezzati,Federico Conti,Dario Bernacchia,Matteo Siano,Letizia Oreni,Stefano Rusconi,Cristina Gervasoni,Anna Lisa Ridolfo,Giuliano Rizzardini,Spinello Antinori,Massimo Galli +11 more
TL;DR: Survey shows that OTDs are fairly frequent in patients with SARS-CoV-2 infection and may precede the onset of full-blown clinical disease, which could explain the underlying pathogenetic mechanism of taste and olfactory disorders in SARS.
Posted ContentDOI
Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients
TL;DR: This article analyzed bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium that express molecules that mediate infection by SARS-CoV-2 (CoV2), the causal agent in COVID-19.
Journal ArticleDOI
Identification of Viruses in Patients With Postviral Olfactory Dysfunction
Motohiko Suzuki,Koichi Saito,Wei-Ping Min,Costin Vladau,Kazunori Toida,Hirotaka Itoh,Shingo Murakami +6 more
TL;DR: Cusative viruses of postviral olfactory dysfunction (PVOD) have not yet been identified and the aim of this study was to investigate causative viruses in patients with PVOD.
Related Papers (5)
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.
Jerome R. Lechien,Carlos M. Chiesa-Estomba,Daniele R De Siati,Mihaela Horoi,Serge D Le Bon,Alexandra Rodriguez,Didier Dequanter,Serge Blecic,Fahd El Afia,Lea Distinguin,Younes Chekkoury-Idrissi,Stéphane Hans,Irene Lopez Delgado,Christian Calvo-Henriquez,Philippe Lavigne,Chiara Falanga,Maria Rosaria Barillari,Giovanni Cammaroto,Mohamad Khalife,Pierre Leich,Christel Souchay,Camelia Rossi,Fabrice Journe,Julien Hsieh,Myriam Edjlali,Myriam Edjlali,Robert Carlier,Laurence Ris,Andrea Lovato,Cosimo de Filippis,Frédérique Coppée,Nicolas Fakhry,Tareck Ayad,Sven Saussez +33 more
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
Real-time tracking of self-reported symptoms to predict potential COVID-19.
Cristina Menni,Ana M. Valdes,Ana M. Valdes,Maxim B. Freidin,Carole H. Sudre,Long H. Nguyen,David A. Drew,Sajaysurya Ganesh,Thomas Varsavsky,M. Jorge Cardoso,Julia S. El-Sayed Moustafa,Alessia Visconti,Pirro G. Hysi,Ruth C. E. Bowyer,Massimo Mangino,Massimo Mangino,Mario Falchi,Jonathan Wolf,Sebastien Ourselin,Andrew T. Chan,Claire J. Steves,Tim D. Spector +21 more