Journal ArticleDOI
Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives.
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TLDR
The potential mechanisms by which omega-3 fatty acids reduce cardiovascular disease risk are reviewed, including prevention of arrhythmias as well as lowering heart rate and blood pressure, decreasing platelet aggregation, and lowering triglyceride levels.About:
This article is published in Atherosclerosis.The article was published on 2008-03-01. It has received 566 citations till now. The article focuses on the topics: Docosahexaenoic acid & Eicosapentaenoic acid.read more
Citations
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Triglycerides and Cardiovascular Disease A Scientific Statement From the American Heart Association
Michael Miller,Neil J. Stone,Christie M. Ballantyne,Vera Bittner,Michael H. Criqui,Henry N. Ginsberg,Anne C. Goldberg,William James Howard,Marc S. Jacobson,Penny M. Kris-Etherton,Terry A. Lennie,Moshe Levi,Theodore Mazzone,Subramanian Pennathur +13 more
TL;DR: The role of triglyceride-rich lipoproteins (TRLs) in the evaluation and management of CVD risk was discussed in this article, where the authors highlighted approaches aimed at minimizing the adverse public health-related consequences associated with hypertriglyceridemic states.
Triglycerides and Cardiovascular Disease : A Scientific Statement From the
Journal ArticleDOI
Functional Roles of Fatty Acids and Their Effects on Human Health
TL;DR: It would seem more appropriate to describe biological effects and health impacts of individual named fatty acids, although it is recognized that this would be a challenge when communicating outside of an academic environment (eg, to consumers).
Journal ArticleDOI
The Mediterranean Diet, its Components, and Cardiovascular Disease
TL;DR: The potential for the Mediterranean diet to act as a key player in cardiovascular disease prevention, and attempt to identify certain aspects of the diet that are particularly beneficial for cardioprotection are highlighted.
Journal ArticleDOI
Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
Yuriko Adkins,Darshan S. Kelley +1 more
TL;DR: Evidence from cellular and molecular research studies indicates that the cardioprotective effects of n-3 PUFA result from a synergism between multiple, intricate mechanisms that involve antiinflammation, proresolving lipid mediators, modulation of cardiac ion channels, reduction of triglycerides, influence on membrane microdomains and downstream cell signaling pathways and antithrombotic and antiarrhythmic effects.
References
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Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National
William C. Taylor,Nigel Unwin +1 more
Journal ArticleDOI
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
TL;DR: Evidence from epidemiological studies and RCTs will be reviewed, and recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation.
Journal ArticleDOI
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
Mitsuhiro Yokoyama,Hideki Origasa,Masunori Matsuzaki,Yuji Matsuzawa,Yasushi Saito,Yuichi Ishikawa,Shinichi Oikawa,Jun Sasaki,Hitoshi Hishida,Hiroshige Itakura,Toru Kita,Akira Kitabatake,Noriaki Nakaya,Toshiie Sakata,Kazuyuki Shimada,Kunio Shirato +15 more
TL;DR: Testing the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish found it to be a promising treatment.
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