Open AccessProceedings Article
Online synthesis for error recovery in digital microfluidic biochips with operation variability
Mirela Alistar,Paul Pop,Jan Madsen +2 more
- pp 53-58
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TLDR
In this paper, the authors proposed an online synthesis strategy to determine the appropriate recovery actions at the moment when faults are detected, which can capture both time and space-redundant and space redundant recovery operations.Abstract:
Microfluidic-based biochips are replacing the conventional biochemical analyzers, and are able to integrate on-chip all the necessary functions for biochemical analysis using microfluidics. The digital microfluidic biochips are based on the manipulation of liquids not as a continuous flow, but as discrete droplets. Researchers have presented approaches for the synthesis of digital microfluidic biochips, which, starting from a biochemical application and a given biochip architecture, determine the allocation, resource binding, scheduling, placement and routing of the operations in the application. The droplet volumes can vary erroneously due to parametric faults, thus impacting negatively the correctness of the application. Researchers have proposed approaches that synthesize offline predetermined recovery subroutines, which are activated online when errors occur. In this paper, we propose an online synthesis strategy, which determines the appropriate recovery actions at the moment when faults are detected. We have also proposed a biochemical application model which can capture both time-redundant and space-redundant recovery operations. Experiments performed on three real-life case studies show that, by taking into account the biochip configuration when errors occur, our online synthesis is able to reduce the application times.read more
Citations
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Journal ArticleDOI
Fast Online Synthesis of Digital Microfluidic Biochips
Daniel Grissom,Philip Brisk +1 more
TL;DR: It is shown that a virtual topology, which constrains the allowable locations of assay operations such as mixing, dilution, sensing, etc., in lieu of traditional placement, can significantly speed up the synthesis process without significantly lengthening assay execution time.
Journal ArticleDOI
Real-Time Error Recovery in Cyberphysical Digital-Microfluidic Biochips Using a Compact Dictionary
TL;DR: This work uses four laboratorial protocols to demonstrate that, compared to software-based methods, the proposed dictionary-based error-recovery method has low response time, and requires a simple experimental setup, and only a small amount of memory.
Journal ArticleDOI
Error-Correcting Sample Preparation with Cyberphysical Digital Microfluidic Lab-on-Chip
TL;DR: This article considers imprecise droplet mix-split operations and presents a novel roll-forward approach where the erroneous droplets are used in the error-recovery process, instead of being discarded or remixed.
Proceedings ArticleDOI
Error recovery in a micro-electrode-dot-array digital microfluidic biochip?
Zipeng Li,Kelvin Yi-Tse Lai,Po-Hsien Yu,Krishnendu Chakrabarty,Miroslav Pajic,Tsung-Yi Ho,Chen-Yi Lee +6 more
TL;DR: By exploiting MEDA-specific advances in droplet sensing, this work presents a novel error-recovery technique to dynamically reconfigure the biochip using real-time data provided by on-chip sensors.
Proceedings ArticleDOI
Rapid online fault recovery for cyber-physical digital microfluidic biochips
TL;DR: This paper introduces a cyber-physical control algorithm that rectifies hard and soft faults that are detected dynamically while executing an assay on a digital microfluidic biochip (DMFB), one specific LoC technology.
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