Journal ArticleDOI
Optical biosensors: where next and how soon?
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TLDR
In this paper, a direct comparison of the technical benefits of labelled reporter assays with the benefits of label-free assays was made. And the authors concluded that label-based assays have significant advantages over label-sensitive assays.About:
This article is published in Drug Discovery Today.The article was published on 2006-12-01. It has received 113 citations till now.read more
Citations
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Survey of the year 2003 commercial optical biosensor literature
Rebecca L. Rich,David G. Myszka +1 more
TL;DR: In this overview, 13 papers that should be on everyone's ‘must read’ list for 2003 are spotlighted and examples of how to identify and interpret high‐quality biosensor data are provided.
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Novel U-bent fiber optic probe for localized surface plasmon resonance based biosensor.
TL;DR: A sensor for sensitive measurement of refractive index (RI) with the help of optical absorbance properties of gold nanoparticles (GNP) coupled to an efficient optical transducer in the form of a U-bent fiber optic probe is described.
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Recent Advances in Resonant Waveguide Gratings
TL;DR: In this paper, the authors discuss the latest developments in the field of Resonant Waveguide gratings (RWGs), including numerical modeling, manufacturing, the physics, and applications of RWGs, and links to the standard tools and references in modeling and fabrication according to their needs.
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A Stable, Label-free Optical Interferometric Biosensor Based on TiO2 Nanotube Arrays
TL;DR: The aqueous stability of the TiO2 nanotube array was examined and compared with porous silica (SiO2), a more extensively studied thin film optical biosensor, which displays significant degradation at pH > 8.
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The application of cell-based label-free technology in drug discovery.
TL;DR: This article has reviewed the various label‐free technologies that are being used in drug discovery settings and has focused the discussion on impedance‐based label‐ free technologies and its main applications indrug discovery.
References
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Journal ArticleDOI
Optical biosensors in drug discovery.
TL;DR: Advances in instrumentation and experimental design have led to the increasing application of optical biosensors in many areas of drug discovery, including target identification, ligand fishing, assay development, lead selection, early ADME and manufacturing quality control.
Journal ArticleDOI
Survey of the year 2003 commercial optical biosensor literature
Rebecca L. Rich,David G. Myszka +1 more
TL;DR: In this overview, 13 papers that should be on everyone's ‘must read’ list for 2003 are spotlighted and examples of how to identify and interpret high‐quality biosensor data are provided.
Journal ArticleDOI
Label-free assays on the BIND system.
Brian T. Cunningham,Peter Li,Stephen C. Schulz,Bo Lin,Cheryl L. Baird,John Gerstenmaier,Christine Genick,Frank Wang,Eric Fine,Lance G. Laing +9 more
TL;DR: SRU Biosystems has developed a biosensor technology that is manufactured on continuous sheets of plastic film and incorporated into standard microplates and microarray slides to enable label-free assays to be performed with high throughput, high sensitivity, and low cost per assay.
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Biosensor analysis of the interaction between immobilized human serum albumin and drug compounds for prediction of human serum albumin binding levels.
Åsa Frostell-Karlsson,Annika Remaeus,Håkan Roos,Karl Andersson,Peter Borg,Markku Hämäläinen,Robert Karlsson +6 more
TL;DR: The interactions between a set of drugs, selected on the basis of reported human serum albumin (HSA) binding levels, and immobilized HSA were investigated using surface plasmon resonance technology and the intensity of the signal obtained from the interaction of the drug with the HSA surface was correlated with the reported HSA binding level.
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Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors.
TL;DR: Results showed that the dynamic mass redistribution in quiescent A431 cells mediated by EGF required EGFR tyrosine kinase activity, actin polymerization, and dynamin and mainly proceeded through MEK.