Journal ArticleDOI
Survey of the year 2003 commercial optical biosensor literature
Rebecca L. Rich,David G. Myszka +1 more
TLDR
In this overview, 13 papers that should be on everyone's ‘must read’ list for 2003 are spotlighted and examples of how to identify and interpret high‐quality biosensor data are provided.Abstract:
In the year 2003 there was a 17% increase in the number of publications citing work performed using optical biosensor technology compared with the previous year. We collated the 962 total papers for 2003, identified the geographical regions where the work was performed, highlighted the instrument types on which it was carried out, and segregated the papers by biological system. In this overview, we spotlight 13 papers that should be on everyone's 'must read' list for 2003 and provide examples of how to identify and interpret high-quality biosensor data. Although we still find that the literature is replete with poorly performed experiments, over-interpreted results and a general lack of understanding of data analysis, we are optimistic that these shortcomings will be addressed as biosensor technology continues to mature.read more
Citations
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Journal ArticleDOI
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
TL;DR: This work presents a meta-analysis of the literature on food quality and safety analysis and its applications in the context of veterinary drugs and drugs and drug-Induced Antibodies, which focuses on the role of canine coronavirus in the veterinary industry.
Journal ArticleDOI
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Michelle R. Arkin,James A. Wells +1 more
TL;DR: Here, illustrative examples are used to discuss general strategies for addressing the challenges inherent in the discovery and characterization of small-molecule inhibitors of protein–protein interactions.
Journal ArticleDOI
Making it stick: convection, reaction and diffusion in surface-based biosensors.
TL;DR: This work develops a physically intuitive and practical understanding of analyte transport for researchers who develop and employ biosensors based on surface capture, and derives order-of-magnitude estimates for fundamental quantities of interest, such as fluxes, collection rates and equilibration times.
Journal ArticleDOI
Long-range surface plasmon polaritons
TL;DR: Long-range surface plasmon polaritons (LRSPPs) are optical surface waves that propagate along a thin symmetric metal slab or stripe over an appreciable length as discussed by the authors.
Journal ArticleDOI
Plasmonic Surface Lattice Resonances: A Review of Properties and Applications
TL;DR: The basic physical principles and properties of plasmonic surface lattice resonances are described: the width and quality of the resonances, singularities of the light phase, electric field enhancement, etc.
References
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Journal ArticleDOI
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Lyubomir T. Vassilev,Binh Thanh Vu,Bradford Graves,Daisy Carvajal,Frank John Podlaski,Zoran Filipovic,Norman Kong,Ursula Kammlott,Christine Lukacs,Christian Klein,Nader Fotouhi,Liu Emily Aijun +11 more
TL;DR: In this article, the authors identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
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Present and future of surface plasmon resonance biosensors.
TL;DR: Fundamentals of SPR affinity biosensors are reviewed and recent advances in development and applications of SPR biosensor are discussed.
Journal ArticleDOI
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
Lin Chen,Simon N. Willis,Andrew H. Wei,Brian J. Smith,Jamie I. Fletcher,Mark G. Hinds,Peter M. Colman,Catherine L. Day,Jerry M. Adams,David C.S. Huang +9 more
TL;DR: The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets.
Journal ArticleDOI
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
TL;DR: In this paper, the authors used surface plasmon resonance spectroscopy and self-assembled monolayers (SAMs) to determine the characteristics of functional groups that give surfaces the ability to resist the nonspecific adsorption of proteins from solution.