Journal ArticleDOI
Oral administration of 3,3'-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis.
K.A. Gandhi,Jayant Sastri Goda,V.V. Gandhi,A. Sadanpurwala,V.K. Jain,Kusum Joshi,S. Epari,Swapnil Rane,Bhabani Mohanty,Pradip Chaudhari,S. Kembhavi,Amit Kunwar,Amit Kunwar,Vikram Gota,K.I. Priyadarsini,K.I. Priyadarsini +15 more
TLDR
DSePA offers protection to normal lung against RP without affecting radiation sensitivity of tumors, and has the potential to be developed as an oral agent for preventing RP.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2019-09-12. It has received 20 citations till now. The article focuses on the topics: Pneumonitis.read more
Citations
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Journal ArticleDOI
Photosensitizer‐Modified MnO 2 Nanoparticles to Enhance Photodynamic Treatment of Abscesses and Boost Immune Protection for Treated Mice
Chenya Wang,Yuanpeng Xiao,Wenwen Zhu,Jiacheng Chu,Jun Xu,He Zhao,Fengyun Shen,Rui Peng,Zhuang Liu +8 more
TL;DR: An antibacterial nanoagent capable of modulating the abscess microenvironment is designed to enhance photodynamic treatment of skin abscesses, and subsequently activate the immune system to effectively prevent abscess recurrence.
Journal ArticleDOI
A Rosetta Stone for Breast Cancer: Prognostic Value and Dynamic Regulation of Neutrophil in Tumor Microenvironment.
Wei Zhang,Yimin Shen,Huanhuan Huang,Sheng Pan,Jingxin Jiang,Wuzhen Chen,Ting Zhang,Chao Zhang,Chao Ni +8 more
TL;DR: The utility of circulating neutrophils for predicting prognosis and therapeutic efficacy and the underlying mechanisms of their chemotaxis, the dynamic regulation of their antitumor or protumor functions and their different spatial distributions in tumor microenvironment are discussed.
Journal ArticleDOI
Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways.
Heba A. Mohamed,Riham S. Said +1 more
TL;DR: In this paper, the authors demonstrated the prophylactic role of coenzyme Q10 (CoQ10), a powerful antioxidant, against radiotherapy-induced gastrointestinal injury in male Sprague Dawley rats.
Journal ArticleDOI
Effects of radiation and role of plants in radioprotection: A critical review.
Mohammed Junaid Hussain Dowlath,Sathish Kumar Karuppannan,Pamela Sinha,Nihala Sultana Dowlath,Kantha Deivi Arunachalam,Balasubramani Ravindran,S. Woong Chang,Phuong Nguyen-Tri,Dinh Duc Nguyen +8 more
TL;DR: This review intends to discuss the effects of ionizing radiation on biological systems and evaluate plant-based radioprotectants that have tested thus far as well as their mechanism of action in protecting against the toxic effects of radiation.
Journal ArticleDOI
3,3′-Diselenodipropionic acid (DSePA): A redox active multifunctional molecule of biological relevance
TL;DR: Research work on DSePA reported in fifteen years or so indicates that it is a promising multifunctional organoselenium compound exhibiting many important activities of biological relevance apart from radioprotection.
References
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Journal ArticleDOI
A fluorometric method for determination of oxidized and reduced glutathione in tissues.
Paul J. Hissin,Russell Hilf +1 more
TL;DR: Results for GSH levels agreed well with earlier reports but levels of GSSG estimated here were higher than earlier reported values, and the reasons for the apparently higher levels ofGSSG are discussed.
Book ChapterDOI
[44] Glutathione peroxidase
TL;DR: This chapter presents a procedure for the preparation of glutathione peroxidase, which is regarded as a major protective system against endogenously and exogenously induced lipid peroxidation.
Journal ArticleDOI
Western blot: technique, theory, and trouble shooting.
Tahrin Mahmood,Ping-Chang Yang +1 more
TL;DR: This paper will attempt to explain the technique and theory behind western blot, and offer some ways to troubleshoot.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Myeloperoxidase: a key regulator of neutrophil oxidant production.
TL;DR: Given the numerous reactions of myeloperoxidase, all its activities should be considered when assessing the injurious oxidants produced by neutrophils.