Oral Nutritional Supplements Containing (n-3) Polyunsaturated Fatty Acids Affect the Nutritional Status of Patients with Stage III Non-Small Cell Lung Cancer during Multimodality Treatment
Barbara S. van der Meij,Jacqueline A.E. Langius,Egbert F. Smit,Marieke D. Spreeuwenberg,B. Mary E. von Blomberg,Annemieke C. Heijboer,Marinus A. Paul,Paul A. M. van Leeuwen +7 more
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In conclusion, a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids beneficially affects nutritional status during multimodality treatment in patients with NSCLC.Abstract:
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), (n-3) fatty acids from fish oil, have immune-modulating effects and may improve nutritional status in cancer. The objective of this study was to investigate the effects of an oral nutritional supplement containing (n-3) fatty acids on nutritional status and inflammatory markers in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment. In a double-blind experiment, 40 patients with stage III NSCLC were randomly assigned to receive 2 cans/d of a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids (2.0 g EPA + 0.9 g DHA/d) or an isocaloric control supplement. EPA in plasma phospholipids, energy intake, resting energy expenditure (REE), body weight, fat free mass (FFM), mid-upper arm circumference (MUAC), and inflammatory markers were assessed. Effects of intervention were analyzed by generalized estimating equations and expressed as regression coefficients (B). The intervention group (I) had a better weight maintenance than the control (C) group after 2 and 4 wk (B = 1.3 and 1.7 kg, respectively; P < 0.05), a better FFM maintenance after 3 and 5 wk (B = 1.5 and 1.9 kg, respectively; P < 0.05), a reduced REE (B = -16.7% of predicted; P = 0.01) after 3 wk, and a trend for a greater MUAC (B = 9.1; P = 0.06) and lower interleukin-6 production (B = -27.9; P = 0.08) after 5 wk. After 4 wk, the I group had a higher energy and protein intake than the C group (B = 2456 kJ/24 h, P = 0.03 and B = 25.0 g, P = 0.01, respectively). In conclusion, a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids beneficially affects nutritional status during multimodality treatment in patients with NSCLC.read more
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ESPEN guidelines on nutrition in cancer patients
Jann Arends,Patrick Bachmann,Vickie E. Baracos,Nicole Barthelemy,Hartmut Bertz,Federico Bozzetti,Kenneth C. H. Fearon,Elisabeth Hütterer,Elizabeth Isenring,Stein Kaasa,Zeljko Krznaric,Barry Laird,Maria Larsson,Alessandro Laviano,Stefan Mühlebach,Maurizio Muscaritoli,Line Merethe Oldervoll,Paula Ravasco,Tora Skeidsvoll Solheim,Florian Strasser,Marian A. E. de van der Schueren,Jean-Charles Preiser +21 more
TL;DR: These evidence-based guidelines were developed to translate current best evidence and expert opinion into recommendations for multi-disciplinary teams responsible for identification, prevention, and treatment of reversible elements of malnutrition in adult cancer patients.
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Understanding the mechanisms and treatment options in cancer cachexia
TL;DR: The combination of therapies into a standard multimodal package coupled with the development of novel therapeutics promises a new era in supportive oncology whereby quality of life and tolerance to cancer therapy could be improved considerably.
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Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults.
TL;DR: A recent review revealed considerable variability in blood levels of omega-3 polyunsaturated fatty acids and the very low to low range of blood EPA+DHA for most of the world may increase global risk for chronic disease as mentioned in this paper.
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Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
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TL;DR: It is demonstrated that endogenous mesenchymal stem cells (MSCs) become activated during treatment with platinum analogs and secrete factors that protect tumor cells against a range of chemotherapeutic agents.
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Dietary sources of omega 3 fatty acids: public health risks and benefits.
TL;DR: The aim of this paper was to review main scientific evidence regarding the public health risks and benefits of the dietary sources of omega-3 fatty acids.
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