Journal ArticleDOI
Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants.
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TLDR
Infloran as probiotics fed enterally with breast milk reduces the incidence and severity of NEC in VLBW infants.Abstract:
Objective. We evaluated the efficacy of probiotics in reducing the incidence and severity of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants. Patients and Methods. A prospective, masked, randomized control trial was conducted to evaluate the beneficial effects of probiotics in reducing the incidence and severity of NEC among VLBW ( Results. Three hundred sixty-seven infants were enrolled: 180 in the study group and 187 in the control group. The demographic and clinical variables were similar in both groups. The incidence of death or NEC (≥ stage 2) was significantly lower in the study group (9 of 180 vs 24 of 187). The incidence of NEC (≥ stage 2) was also significantly lower in the study when compared with the control group (2 of 180 vs 10 of 187). There were 6 cases of severe NEC (Bell stage 3) in the control group and none in the study group. None of the positive blood culture grew Lactobacillus or Bifidobacterium species. Conclusion. Infloran as probiotics fed enterally with breast milk reduces the incidence and severity of NEC in VLBW infants.read more
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Journal ArticleDOI
The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
TL;DR: This meta-analysis of RCT and observational studies found that the use of probiotics was beneficial for the prevention of severe NEC, late-onset sepsis, and all-cause mortality in VLBW infants.
Journal ArticleDOI
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota
Christian Milani,Sabrina Duranti,Francesca Bottacini,Eoghan Casey,Francesca Turroni,Jennifer Mahony,Clara Belzer,Susana Delgado Palacio,Silvia Arboleya Montes,Leonardo Mancabelli,Gabriele Andrea Lugli,Juan M. Rodríguez,Lars Bode,Willem M. de Vos,Willem M. de Vos,Miguel Gueimonde,Abelardo Margolles,Douwe van Sinderen,Marco Ventura +18 more
TL;DR: The infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions are described and the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease are discussed.
Reference EntryDOI
Probiotics for prevention of necrotizing enterocolitis in preterm infants
Khalid AlFaleh,Jasim Anabrees +1 more
TL;DR: Enteral supplementation of probiotics prevents severe NEC and all cause mortality in preterm infants and a change in practice is strongly supported.
Journal ArticleDOI
16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis
Yunwei Wang,Jeanette D. Hoenig,Kathryn J. Malin,Sanaa Qamar,Elaine O. Petrof,Jun Sun,Dionysios A. Antonopoulos,Eugene B. Chang,Erika C. Claud +8 more
TL;DR: The results suggest that NEC is associated with severe lack of microbiota diversity that may accentuate the impact of single dominant microorganisms favored by empiric and widespread use of antibiotics.
Journal ArticleDOI
Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates.
Alona Bin-Nun,Ruben Bromiker,Michael Wilschanski,Michael J. Kaplan,Bernard Rudensky,Michael S. Caplan,Cathy Hammerman +6 more
TL;DR: Probiotic supplementation reduced both the incidence and severity of NEC in the premature neonatal population and was less severe in the probiotic-supplemented infants.
References
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Journal ArticleDOI
Breast milk and neonatal necrotising enterocolitis
Alan Lucas,Tim J Cole +1 more
TL;DR: With the fall in the use of breast milk in British neonatal units, exclusive formula feeding could account for an estimated 500 extra cases of necrotising enterocolitis each year, and about 100 infants would die.
Journal ArticleDOI
Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study.
TL;DR: Seven days of Lactobacillus GG supplementation starting with the first feed is not effective in reducing the incidence of UTIs, NEC and sepsis in preterm infants.
Journal ArticleDOI
Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection.
TL;DR: Bacterial adhesion to enterocytes, fecal colonization, or both seem to be valuable selection criteria for immunomodulation, and antiinfective mechanisms of defense can be enhanced after ingestion of specific lactic acid bacteria strains.
Journal ArticleDOI
Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit
TL;DR: The hypothesis that oral administration of prophylactic Lactobacillus acidophilus and Bifidobacterium infantis to all neonates in an intensive care unit, would decrease the incidence of NEC is examined and support the need for further investigation of bacterial colonization and its role in NEC.
Journal ArticleDOI
Necrotizing Enterocolitis Among Neonates in the United States
TL;DR: It was found that exposure to antenatal glucocorticoids was associated with an increased risk for NEC independent of birth weight, which remains an important cause of morbidity and mortality in prematurely born neonates.