Journal ArticleDOI
Organocatalysed asymmetric Mannich reactions.
TLDR
This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.Abstract:
The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C–C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.read more
Citations
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Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
Journal ArticleDOI
Catalytic Enantioselective Formation of C−C Bonds by Addition to Imines and Hydrazones: A Ten-Year Update
Journal ArticleDOI
Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions
Albert Moyano,Ramon Rios +1 more
Journal ArticleDOI
Recent Developments in Asymmetric Organocatalytic Domino Reactions
TL;DR: The field of asymmetric organocatalytic biomolecular cascades has become one of the most fascinating and current fields in organic chemistry as discussed by the authors, and the literature has been rapidly developing.
References
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Highly enantioselective organocatalytic addition of unmodified aldehydes to N-Boc protected imines: one-pot asymmetric synthesis of β-amino acids
TL;DR: Highly enantioselective catalytic routes to Boc protected?-amino aldehydes, amino acids and amino alcohols are presented in this paper.
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4‐Aminothiourea Prolinol tert‐Butyldiphenylsilyl Ether: A Chiral Secondary Amine‐Thiourea as Organocatalyst for Enantioselective anti‐Mannich Reactions
TL;DR: The study demonstrated for the first time that direct Mannich-type reactions of unmodified aldehydes or ketones to α-iminoglyoxylate can be promoted by secondary amine-thiourea chiral organocatalyst.
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Highly Enantioselective Organocatalytic Addition of Aldehydes to N-(Phenylmethylene)benzamides : Asymmetric Synthesis of the Paclitaxel Side Chain and Its Analogues
TL;DR: Easily side-tracked: A simple route to the paclitaxel side chain and its analogues is based on the (R)-proline-catalyzed addition of aldehydes to N-(phenylmethylene)benzamides, followed by oxidation of the resulting protected alpha-hydroxy-beta-benzoylaminoaldehydes.
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Enantioselective Trifunctional Organocatalysts for Rate-Enhanced Aza-Morita-Baylis-Hillman Reactions at Room Temperature
TL;DR: A Bronsted acid-activated trifunctional organocatalyst, based on the BINAP scaffold, was used for the first time to catalyze aza-Morita-Baylis-Hillman reactions between N-tosylimines and methyl vinyl ketone with fast reaction rates and good enantioselectivity at room temperature.
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Acyclic β-amino acid catalyzed asymmetric anti-selective Mannich-type reactions
Pawel Dziedzic,Armando Córdova +1 more
TL;DR: The ability of a primary amine containing acyclic beta(3)-amino acids to catalyze direct asymmetric anti-selective Mannich-type reactions is presented in this article.