Journal ArticleDOI
Organocatalysed asymmetric Mannich reactions.
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TLDR
This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.Abstract:
The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C–C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.read more
Citations
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Journal ArticleDOI
A novel quaternary ammonium salts derived from α-amino acids with large steric hindrance group and its application in asymmetric Mannich reaction
TL;DR: In this article, a quaternary ammonium salt derived from amino acids with large steric hindrance group was designed and synthesized, which promoted the asymmetric Mannich reaction of glycine imines with N-Boc-aldimines in excellent yields with high enantio- and diastereo-control compared with known catalysts of this type reported by their group.
Journal ArticleDOI
β-Amino functionalization of cinnamic Weinreb amides in ionic liquid.
TL;DR: 2-Ns-Protected β-amino Weinreb amides were synthesized by aminochlorination of α,β-unsaturated Wein Reb amides in an ionic liquid, 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([BMIM][NTf2].
Book ChapterDOI
Enantioselective Synthesis of Amines by Chiral Brønsted Acid Catalysts
Masahiro Terada,Norie Momiyama +1 more
Patent
New enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof
László G. Puskás,Iván Kanizsai,Thierry Pillot,Gyuris Mario,András Szabó,Ferenc Takacs,Hackler Laszlo +6 more
TL;DR: In this paper, a novel enantiomer derivatives of 8-hydroxyquinoline derivatives with general formula (I) and (II) and the synthesis thereof and pharmaceutically acceptable salts and metal complexes and thereof, and the medicinal and/or pharmaceutical compositions comprising these compounds.
References
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Book
Protective groups in organic synthesis
TL;DR: In this article, the most useful groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups are discussed and the chemistry of the classes of these groups, as well as that of individual groups within the class using structures, equations and references.
Journal ArticleDOI
Proline-Catalyzed Direct Asymmetric Aldol Reactions
TL;DR: The finding that the amino acid proline is an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone and a variety of aldehydes is reported.
Book
Greene's Protective Groups in Organic Synthesis
TL;DR: The role of protection groups in organic synthesis is discussed in this paper, where the authors present several general methods for phosphate Ester formation. But none of these methods are suitable for practical applications.
Journal ArticleDOI
Enantioselective Mannich‐Type Reaction Catalyzed by a Chiral Brønsted Acid
Journal ArticleDOI
Chiral Brønsted acid-catalyzed direct Mannich reactions via electrophilic activation.
Daisuke Uraguchi,Masahiro Terada +1 more
TL;DR: It was found that the phosphoric acid derivatives of general structure 1 serve as highly effective catalysts for the direct addition of acetyl acetone to N-Boc-protected arylimines and functions as an excellent catalyst.