Journal ArticleDOI
Organocatalysed asymmetric Mannich reactions.
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TLDR
This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.Abstract:
The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C–C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.read more
Citations
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Journal ArticleDOI
Recent Advances in Organocatalyzed Domino C–C Bond-Forming Reactions
Cleo S Evans,Lindsey O. Davis +1 more
TL;DR: This review will focus on recent advances in organocatalysis with an emphasis on methodologies having applications in the synthesis of biologically-significant compounds.
Journal ArticleDOI
Nucleophilic and Electrophilic Activation of Non‐Heteroaromatic Amides in Atom‐Economical Asymmetric Catalysis
TL;DR: The Minireview summarizes recent developments in catalytic asymmetric carbon-carbon bond-forming reactions of non-heteroaromatic amide substrates, rendering these amides amenable to enantioselective reactions with perfect atom economy, producing synthetically useful chiral building blocks.
Journal ArticleDOI
An unusual Mannich type reaction of tertiary aromatic amines in aqueous micelles
Atul Kumar,Ram Awatar Maurya +1 more
TL;DR: In this paper, an efficient Mannich type reaction of tertiary aromatic amines, formaldehyde and 1,3-dicarbonyl compounds is described in aqueous micelles catalyzed by boric acid to afford dialkylaminoarylated 1.3-Dicaronyls.
Journal ArticleDOI
Enantioselective conjugate addition of hydroxylamines to α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(III) complex
TL;DR: A catalytic enantioselective hydroxyamination of α,β-unsaturated 2-acyl imidazoles with N-protected hydroxyl amines catalyzed by a chiral-at-metal Rh(III) complex has been developed and affords valuable N-Boc protected β-amino acid derivatives in moderate to good yields with high enantiOSElectivity.
Journal ArticleDOI
Squaramide-catalysed enantionselective Mannich reaction of imines bearing a heterocycle with malonates
Hai‐Xiao He,Da-Ming Du +1 more
TL;DR: An efficient enantioselective Mannich reaction of imines bearing a heterocycle with malonates catalysed by a cinchona-based squaramide organocatalyst has been developed and afforded the β-amino ester derivatives containing aheterocycle moiety in high yields and excellent enantiOSElectivities in most cases.
References
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Book
Protective groups in organic synthesis
TL;DR: In this article, the most useful groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups are discussed and the chemistry of the classes of these groups, as well as that of individual groups within the class using structures, equations and references.
Journal ArticleDOI
Proline-Catalyzed Direct Asymmetric Aldol Reactions
TL;DR: The finding that the amino acid proline is an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone and a variety of aldehydes is reported.
Book
Greene's Protective Groups in Organic Synthesis
TL;DR: The role of protection groups in organic synthesis is discussed in this paper, where the authors present several general methods for phosphate Ester formation. But none of these methods are suitable for practical applications.
Journal ArticleDOI
Enantioselective Mannich‐Type Reaction Catalyzed by a Chiral Brønsted Acid
Journal ArticleDOI
Chiral Brønsted acid-catalyzed direct Mannich reactions via electrophilic activation.
Daisuke Uraguchi,Masahiro Terada +1 more
TL;DR: It was found that the phosphoric acid derivatives of general structure 1 serve as highly effective catalysts for the direct addition of acetyl acetone to N-Boc-protected arylimines and functions as an excellent catalyst.