Journal ArticleDOI
Organocatalysed asymmetric Mannich reactions.
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TLDR
This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.Abstract:
The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C–C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.read more
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Copper(II)‐Catalyzed Synthesis of Indoloquinoxalin‐6‐ones through Oxidative Mannich Reaction
TL;DR: In this article, a Cu-catalyzed synthesis of indoloquinoxalin-6-one has been developed that starts from o-indolyl-N,N-dialkylamines through sp3 C-H bond oxidation α to the nitrogen atom with di-tert-butyl peroxide as oxidant.
Journal ArticleDOI
Enantio- and Diastereoselective Double Mannich Reaction between Ketones and Imines Catalyzed by Zn-ProPhenol.
TL;DR: A Zn-ProPhenol-catalyzed double Mannich reaction between ynones and imines that generates 1,3-diamines in excellent yield as well as diastereo- and enantioselectivity (>99.5% ee) is presented.
Journal ArticleDOI
The first bromide ion directed double helicate and its role in catalysis
Paulraj Mosae Selvakumar,P. Yowan Jebaraj,Jashobanta Sahoo,Eringathodi Suresh,K. Jeya Prathap,Rukhsana I. Kureshy,Palani S. Subramanian +6 more
TL;DR: A bromide ion directed double stranded helicate is synthesized and its structure is reported for the first time in this paper, and a series of β-aminocarbonyls using this water soluble helicate as a catalyst for a three-component amionalkylation reaction is also explored by adopting solvent-free reaction conditions.
Journal ArticleDOI
Efficient Mannich Reaction Using Iminium Salts Generated from Glycine Derivatives
TL;DR: Iminium salts generated by the oxidation of amino ketene silyl acetals underwent a facile Mannich reaction with another ketene Silyl Acetal to give aspartic acid derivatives in good yields.
Journal ArticleDOI
Thermal behavior and kinetics of enzymatic hydrolysis lignin modified products
Xinyu Lu,Peng Dai,Xiaojun Zhu,Haoquan Guo,Han Que,Dandan Wang,Dingxiang Liang,Tao He,Dong Yuguo,Li Liang,Chengjuan Hu,Chaozhong Xu,Zhenyang Luo,Xiaoli Gu +13 more
TL;DR: In this article, the pyrolysis behavior and kinetics of lignin modified products via thermogravimetric analyzer coupled with Fourier transform infrared spectrometry (TG-FTIR) were investigated.
References
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Book
Protective groups in organic synthesis
TL;DR: In this article, the most useful groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups are discussed and the chemistry of the classes of these groups, as well as that of individual groups within the class using structures, equations and references.
Journal ArticleDOI
Proline-Catalyzed Direct Asymmetric Aldol Reactions
TL;DR: The finding that the amino acid proline is an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone and a variety of aldehydes is reported.
Book
Greene's Protective Groups in Organic Synthesis
TL;DR: The role of protection groups in organic synthesis is discussed in this paper, where the authors present several general methods for phosphate Ester formation. But none of these methods are suitable for practical applications.
Journal ArticleDOI
Enantioselective Mannich‐Type Reaction Catalyzed by a Chiral Brønsted Acid
Journal ArticleDOI
Chiral Brønsted acid-catalyzed direct Mannich reactions via electrophilic activation.
Daisuke Uraguchi,Masahiro Terada +1 more
TL;DR: It was found that the phosphoric acid derivatives of general structure 1 serve as highly effective catalysts for the direct addition of acetyl acetone to N-Boc-protected arylimines and functions as an excellent catalyst.