Journal ArticleDOI
Organocatalysed asymmetric Mannich reactions.
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TLDR
This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.Abstract:
The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C–C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.read more
Citations
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FeCl2 Catalyzed Three-Component Reactions of Phospholes, Pyrrolidine, and Ketones (Aldehydes): Chemoselective Synthesis of 1-Phosphafulvenes.
TL;DR: In this article, an unprecedented approach for the synthesis of transient 1-phosphafulvenes through three component reactions of phospholes was developed, which was demonstrated by in situ cycloaddition with 2H-phospholes and [6 + 6] self-dimerization.
Journal ArticleDOI
Enantioselective amination of acyclic α-alkylated β-keto esters catalyzed by chiral lithium binaphtholate
TL;DR: In this paper, the enantioselective amination of α-alkylated β-keto esters with azodicarboxylates using a chiral dilithium binaphtholate as catalyst affords optically active α,α-disubstituted α-amino acid derivatives in up to 95% ee.
Journal ArticleDOI
A Novel Method for the Synthesis of Newfangled Asymmetric Schiff Bases from α-amino Acids under Ultrasonic Conditions and in Aqueous Medium
Kıvılcım Şendil,Kıvılcım Şendil,Turgay Tekin,Haydar Göksu,Haydar Göksu,Mehmet Oğuz,Baris Anil,Mehmet Serdar Gültekin +7 more
TL;DR: Aryl aldehydes and chiral α-amino acids were synthesized in the presence of H3PO4 in ethanol at 80°C for 24'h, and K2CO3 under ultrasonic conditions in an aqueous ethanol medium within 5'min with yields reaching up to 96% as mentioned in this paper.
Journal ArticleDOI
Phospha-Mannich reactions of PH3 and its analogs
Dmitry V. Moiseev,Brian R. James +1 more
TL;DR: In this article, the use of PH3 and its liquid analog (Me3Si)3P in such reactions is rare, because of toxicity and inflammability, applications of PH 3 and their liquid analog Me3Si3P are rare.
References
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Book
Protective groups in organic synthesis
TL;DR: In this article, the most useful groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups are discussed and the chemistry of the classes of these groups, as well as that of individual groups within the class using structures, equations and references.
Journal ArticleDOI
Proline-Catalyzed Direct Asymmetric Aldol Reactions
TL;DR: The finding that the amino acid proline is an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone and a variety of aldehydes is reported.
Book
Greene's Protective Groups in Organic Synthesis
TL;DR: The role of protection groups in organic synthesis is discussed in this paper, where the authors present several general methods for phosphate Ester formation. But none of these methods are suitable for practical applications.
Journal ArticleDOI
Enantioselective Mannich‐Type Reaction Catalyzed by a Chiral Brønsted Acid
Journal ArticleDOI
Chiral Brønsted acid-catalyzed direct Mannich reactions via electrophilic activation.
Daisuke Uraguchi,Masahiro Terada +1 more
TL;DR: It was found that the phosphoric acid derivatives of general structure 1 serve as highly effective catalysts for the direct addition of acetyl acetone to N-Boc-protected arylimines and functions as an excellent catalyst.