Journal ArticleDOI
Osteoclasts and osteoblasts migrate in opposite directions in response to a constant electrical field.
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TLDR
In vitro, the effects of the electrical field produced by constant current on freshly isolated rabbit osteoclasts and well characterized clonal rat osteoblastlike cells showed that different cell types from the same tissue can respond differently to the same electrical signal.Abstract:
We have investigated in vitro the effects of the electrical field produced by constant current on freshly isolated rabbit osteoclasts and on well characterized clonal rat osteoblastlike cells. At field strengths of 0.1 and 1 V/mm, the osteoclasts migrated rapidly toward the positive electrode, whereas the osteoblastlike cells migrated in the opposite direction, toward the negative electrode. Thus, different cell types from the same tissue can respond differently to the same electrical signal. These results have important implications for hypotheses concerning the cellular mechanism of galvanotaxis, and may also clarify the cellular basis of the clinical application of electrical stimulation of bone healing.read more
Citations
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Journal ArticleDOI
Controlling Cell Behavior Electrically: Current Views and Future Potential
TL;DR: This review aims to resolve issues by describing the historical context of bioelectricity, the fundamental principles of physics and physiology responsible for DC electric fields within cells and tissues, the cellular mechanisms for the effects of small electric fields on cell behavior, and the clinical potential for electric field treatment of damaged tissues.
Journal ArticleDOI
Bone cell biology: the regulation of development structure, and function in the skeleton
Sandy C. Marks,Steven N. Popoff +1 more
TL;DR: Any understanding of bone cell regulation is a key ingredient in understanding not only the development, maintenance, and repair of the skeleton but also the prevention and treatment of skeletal disorders.
Journal ArticleDOI
Electromagnetic effects - From cell biology to medicine.
TL;DR: This review tries to link areas of EF, MF and EMF research to thermodynamics and quantum physics, approaches that will produce novel insights into cell biology.
Journal ArticleDOI
Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts.
TL;DR: It is suggested that M-CSF continues to modulate osteoclastic activity once osteoclasts are on resorptive sites, through regulation of the balance between resorption and migration, such that not only the quantity, but the spatial pattern of Resorption can be controlled by adjacent M- CSF- secreting cells of osteoblastic lineage.
Journal ArticleDOI
Piezoelectric polymers as biomaterials for tissue engineering applications
TL;DR: The most used materials for tissue engineering strategies are reported together with the main achievements, challenges and future needs for research and actual therapies and a compilation of the most relevant results and strategies are provided.
References
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Journal ArticleDOI
Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations.
TL;DR: The results indicated that enzymatically released calvaria cells can form mineralized bone nodules in vitro in the presence of ascorbic acid and organic phosphate.
Book ChapterDOI
Precursor cells of mechanocytes.
TL;DR: It was found that the differentiation features characteristic of mechanocytes of the source tissue are consistently retained by in vitro descendants of clonogenic cells, thus self-maintained precursors determined to differentiate into definite types of mechanocyte are present in postnatal life.
Journal ArticleDOI
Orientation of neurite growth by extracellular electric fields
Nilesh Patel,MM Poo +1 more
TL;DR: This finding is consistent with the notion that cathodal accumulation of growth-controlling surface glycoproteins by the field is the underlying mechanism of the field-induced orientation of neurite growth toward the cathode.
Journal ArticleDOI
The Responses of Cells to Electrical Fields: A Review
TL;DR: The significance of these recent results is increased by the finding that several cell types that normally migrate or grow long distances in embryos respond directionally to surprisingly small fields, and by the concurrent finding that developing embryos produce substantial endogenous currents.
Journal ArticleDOI
Resorption of bone by isolated rabbit osteoclasts
TL;DR: In this article, a carborundum wheel was used to prepare slices of cortical bone that demonstrate a predictable surface appearance in the scanning electron microscope, and after 24h in culture osteoclasts were associated with areas of excavation in the bone surface.
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