Journal ArticleDOI
Oxidative Stress from Environmental Exposures.
James M. Samet,Phillip A. Wages +1 more
TLDR
Live-cell imaging has proven to be a powerful approach to the study of environmental oxidative stress, and cells are equipped with multiple complementary energy-dependent systems for maintaining redox homeostasis in the face of environmental antioxidant stress.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-02-01. It has received 53 citations till now. The article focuses on the topics: Environmental exposure & Oxidative stress.read more
Citations
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Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
Javier Checa,Josep M Aran +1 more
TL;DR: In-depth knowledge of the molecular mechanisms of ROS actuation and their influence under steady-state and stressful conditions will pave the way for the development of novel therapeutic interventions to mitigate the harmful outcomes of ROS in the onset and progression of a variety of chronic inflammatory and age-related diseases.
Journal ArticleDOI
Twenty-five years of total antioxidant capacity measurement of foods and biological fluids: merits and limitations
TL;DR: The appropriate use of TAC measurement both in food and in vivo can still provide support for the interpretation of complex phenomena and be a tool for sample screening when making a quick decision toward in-depth research investigations.
Journal ArticleDOI
Mechanisms of soft and hard electrophile toxicities.
TL;DR: The purpose of this Review is to discuss electrophile-nucleophile chemistry as it pertains to cell injury and resulting organ toxicity, and an introduction to the Hard and Soft, Acids and Bases (HSAB) theory of Pearson.
Journal ArticleDOI
Source, bioaccumulation, degradability and toxicity of triclosan in aquatic environments: A review
Owias Iqbal Dar,Raouf Aslam,Deng Pan,Sunil Sharma,Megha Andotra,Arvinder Kaur,Ai-Qun Jia,Caterina Faggio +7 more
TL;DR: In this article, a review has been conducted with an objective to highlight the concerns surrounding TCS exposure to aquatic organisms, the infiltration routes into the food chain, its persistence and accumulation, teratogenic, biochemical and cytogenic effects on a wide range of aquatic species.
Journal ArticleDOI
Source, bioaccumulation, degradability and toxicity of triclosan in aquatic environments: A review
TL;DR: In this article , a review has been conducted with an objective to highlight the concerns surrounding TCS exposure to aquatic organisms, the infiltration routes into the food chain, its persistence and accumulation, teratogenic, biochemical and cytogenic effects on a wide range of aquatic species.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Metals, toxicity and oxidative stress.
TL;DR: This review summarizes recent findings in the metal-induced formation of free radicals and the role of oxidative stress in the carcinogenicity and toxicity of metals.
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Modulation of oxidative stress as an anticancer strategy.
TL;DR: The controversial role of ROS in tumour development and in responses to anticancer therapies is addressed, and the idea that targeting the antioxidant capacity of tumour cells can have a positive therapeutic impact is elaborate.
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The thioredoxin antioxidant system.
Jun Lu,Arne Holmgren +1 more
TL;DR: The absence of a GSH-Grx system in some pathogenic bacteria such as Helicobacter pylori, Mycobacterium tuberculosis, and Staphylococcus aureus makes the bacterial Trx system essential for survival under oxidative stress, and provides an opportunity to kill these bacteria by targeting the TrxR-Trx system.
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Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
Vsevolod V. Belousov,Arkady F. Fradkov,Konstantin A. Lukyanov,Dmitry B. Staroverov,Konstantin S Shakhbazov,Alexey V. Terskikh,Alexey V. Terskikh,Sergey Lukyanov +7 more
TL;DR: A genetically encoded, highly specific fluorescent probe for detecting hydrogen peroxide (H2O2) inside living cells, named HyPer, consists of circularly permuted yellow fluorescent protein (cpYFP) inserted into the regulatory domain of the prokaryotic H 2O2-sensing protein, OxyR.