Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience
TLDR
Both conserved and variable features of central oxytocin and vasopressin systems are described in the context of social behavioral diversity, with a particular focus on neural networks that modulate social learning, behavior, and salience of sociosensory stimuli during species‐typical social contexts.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2017-05-01 and is currently open access. It has received 206 citations till now. The article focuses on the topics: Oxytocin receptor & Social learning.read more
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Functional circuit architecture underlying parental behaviour.
Johannes Kohl,Benedicte M. Babayan,Nimrod D. Rubinstein,Anita E. Autry,Brenda Marin-Rodriguez,Vikrant Kapoor,Kazunari Miyamishi,Larry S. Zweifel,Liqun Luo,Naoshige Uchida,Catherine Dulac +10 more
TL;DR: Galanin-expressing neurons in the medial preoptic area of the hypothalamus coordinate different aspects of motor, motivational, hormonal and social behaviour associated with parenting by projecting to different brain regions depending on the type of behaviour and sex and reproductive state of mice.
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The neural mechanisms and circuitry of the pair bond.
TL;DR: How neural representations of a partner become inherently rewarding, providing intriguing insights into the neural origins of love is discussed, in this Review.
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Status-Dependent Vasotocin Modulation of Dominance and Subordination in the Weakly Electric Fish Gymnotus omarorum.
Rossana Perrone,Ana Silva +1 more
TL;DR: This study contributes a clear example of status-dependent AVT modulation of agonistic behavior in teleosts, and reveals distinctive activation patterns of the AVT system between dominants and subordinates.
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Sex Differences in Autism Spectrum Disorder: a Review
TL;DR: Current findings and theories that contribute to male preponderance of neurodevelopmental disorders, with a focus on autism are reviewed, and the possibilities of female underdiagnosis and a multi-hit hypothesis are discussed.
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Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery
Zhimin Song,H. Elliott Albers +1 more
TL;DR: The increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other's canonical receptors is reviewed and the possibility that receptor cross-talk following the synaptic and non-synaptic release of OT andAVP contributes to their distinct roles in the brain and periphery is examined.
References
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CD38 and its role in oxytocin secretion and social behavior.
TL;DR: Data detailing the molecular mechanism of CD38-dependent OXT secretion in CD38 knockout mice is described, which may provide a better understanding of the neuroendocrinological roles of OXT and CD38 in the hypothalamus and of the pathophysiology of ASD.
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Variation in vasopressin receptor (Avpr1a) expression creates diversity in behaviors related to monogamy in prairie voles.
Catherine E. Barrett,Alaine C. Keebaugh,Alaine C. Keebaugh,Todd H. Ahern,Caroline E. Bass,Ernest F. Terwilliger,Larry J. Young,Larry J. Young +7 more
TL;DR: This paper used RNA interference to examine the causal relationship between intraspecific variation in vasopressin 1a receptor gene (V1aR) and behavioral outcomes, by approximating the degree of naturalistic variation in V 1aR expression.
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Functional connectivity among limbic brain areas: differential effects of incubation temperature and gonadal sex in the leopard gecko, Eublepharis macularius
TL;DR: The effects of both incubation temperature and gonadal sex on functional connectivity among limbic brain areas were examined and correlations among preoptic, hypothalamic and amygdalar areas tended to be distributed across both sexes, suggesting that there may be shared pathways underlying the expression of male-Typical and female-typical behaviors.
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A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans.
Chunliang Feng,Chunliang Feng,Adriana Lori,Irwin D. Waldman,Elisabeth B. Binder,Ebrahim Haroon,James K. Rilling +6 more
TL;DR: It is shown that sex differences in OT effects are specific to individuals with the rs53576 GG genotype, and are not found for other genotypes (rs53576 AA/AG), which suggests that rs53575 genotype is an important variable to consider in future investigations of the clinical efficacy of intranasal OT treatment.
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Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors
TL;DR: Combinatorial and natural peptide libraries are likely to play a major role in identifying new GPCR ligands at each of these sites, including the interaction surface that recruits G proteins and arrestins and the interaction sites of additional proteins.