Journal ArticleDOI
Palladium-Catalyzed β-C(sp3)-H Arylation of Aliphatic Ketones Enabled by a Transient Directing Group.
TLDR
In this paper, the direct arylation of aliphatic ketones has been developed via Pd-catalyzed β-C(sp3)-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields.Abstract:
The direct arylation of aliphatic ketones has been developed via Pd-catalyzed β-C(sp3)-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields. Furthermore, the reaction can tolerate abundant substrate of ketones and aryl iodides. This study expands the scope of applications for TDGs.read more
Citations
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Journal ArticleDOI
Transient Directing Groups in Metal-Organic Cooperative Catalysis.
TL;DR: The transient directing group strategy as mentioned in this paper has been widely used for the direct functionalization of C-H bonds and has been shown to be effective in both aromatic and aliphatic substrates.
Journal ArticleDOI
PdII-Catalyzed γ-C(sp3)-H (Hetero)Arylation of Ketones Enabled by Transient Directing Groups.
TL;DR: Pd(II)-catalyzed γ-C(sp3)-H (hetero)arylation of aliphatic ketones is developed using α-amino acid as transient directing groups (TDG) as mentioned in this paper .
Journal ArticleDOI
Rigid α-Diimine Palladium Complexes as Direct C-H Arylation Precatalysts for Thiophenes and Heteroaryl Bromides
TL;DR: In this paper , the direct C-H heteroarylation of thiophenes, promoted by rigid α-diimine palladium complexes, is described, which exhibits broad substrate scopes with functional group tolerant, and proceeds with the formation of regioselective products.
Journal ArticleDOI
ortho-C(sp3)-H arylation of aromatic aldehydes using 2-amino-N-methyl-acetamide as a L,L-type transient directing group.
TL;DR: Pd-catalyzed ortho-C(sp3)-H arylation of aromatic aldehydes using 2-amino-N-methylacetamide as a simple, efficient and commercially available L,L-type transient directing group (TDG) is reported in this article .
Journal ArticleDOI
Transition Metal‐Catalyzed CH Functionalizations Using a Transient Directing Group Approach
TL;DR: In this paper , a transient ligand enables the formation of the directing group in situ and dissociates after the reaction's completion, which is widely known as the transient directing group (TDG) approach.
References
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Journal ArticleDOI
Rhodium-Catalyzed C-C Bond Formation via Heteroatom-Directed C-H Bond Activation
TL;DR: This review focuses on Rh-catalyzed methods for C-H bond functionalization, which have seen widespread success over the course of the last decade and are discussed in detail in the accompanying articles in this special issue of Chemical Reviews.
Journal ArticleDOI
Transition-metal-catalyzed direct arylation of (hetero)arenes by C-H bond cleavage.
TL;DR: P palladium and ruthenium catalysts have been described that enable the direct arylation of (hetero)arenes with challenging coupling partners--including electrophilic aryl chlorides and tosylates as well as simple arenes in cross-dehydrogenative arylations.
Journal ArticleDOI
Systematic overview of warfarin and its drug and food interactions.
Anne Holbrook,Jennifer A. Pereira,Renée Labiris,Heather McDonald,James D. Douketis,Mark Crowther,Philip S. Wells +6 more
TL;DR: The consistency of reports of interactions with azole antibiotics, macrolides, quinolones, nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors, selective serotonin reuptake inhibitors, omeprazole, lipid-lowering agents, amiodarone, and fluorouracil suggests that coadministration with warfarin should be avoided or closely monitored.
Journal ArticleDOI
Palladium-Catalyzed Oxygenation of Unactivated sp3 C−H Bonds
TL;DR: A new palladium-catalyzed method for the oxygenation of unactivated sp3 C-H bonds is described, and the high selectivities are rationalized on the basis of the requirements of putative palladium alkyl intermediates.
Journal ArticleDOI
Intermolecular Amidation of Unactivated sp2 and sp3 C−H Bonds via Palladium-Catalyzed Cascade C−H Activation/Nitrene Insertion
TL;DR: This communication describes the Pd(OAc)2-catalyzed intermolecular amidation reactions of unactivated sp2 and sp3 C-H bonds using primary amides and potassium persulfate, which generated reactive nitrene species which then reacted with the cyclopalladated complex.
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