Pancreatic Cancer Small Extracellular Vesicles (Exosomes): A Tale of Short- and Long-Distance Communication
TLDR
In this article, small extracellular vesicles (sEVs, exosomes) were used as biomarkers for diagnosis and prognosis of pancreatic ductal adenocarcinoma (PDAC).Abstract:
Even with all recent advances in cancer therapy, pancreatic cancer still has a dismal 5-year survival rate of less than 7%. The most prevalent tumor subtype is pancreatic ductal adenocarcinoma (PDAC). PDACs display an extensive crosstalk with their tumor microenvironment (TME), e.g., pancreatic stellate cells, but also immune cells to regulate tumor growth, immune evasion, and metastasis. In addition to crosstalk in the local TME, PDACs were shown to induce the formation of pre-metastatic niches in different organs. Recent advances have attributed many of these interactions to intercellular communication by small extracellular vesicles (sEVs, exosomes). These nanovesicles are derived of endo-lysosomal structures (multivesicular bodies) with a size range of 30-150 nm. sEVs carry various bioactive cargos, such as proteins, lipids, DNA, mRNA, or miRNAs and act in an autocrine or paracrine fashion to educate recipient cells. In addition to tumor formation, progression, and metastasis, sEVs were described as potent biomarker platforms for diagnosis and prognosis of PDAC. Advances in sEV engineering have further indicated that sEVs might once be used as effective drug carriers. Thus, extensive sEV-based communication and applications as platform for biomarker analysis or vehicles for treatment suggest a major impact of sEVs in future PDAC research.read more
Citations
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Journal ArticleDOI
Small extracellular vesicles (exosomes) and their cargo in pancreatic cancer: Key roles in the hallmarks of cancer.
Lily M. Channon,Victoria M. Tyma,Zhihong Xu,David W. Greening,Jeremy S. Wilson,Chamini J. Perera,Minoti V. Apte +6 more
TL;DR: A review of the role of extracellular vesicles, their subtypes and their oncogenic cargo (as characterised by targeted studies as well as agnostic '-omics' analyses) in the pathobiology of pancreatic cancer is presented in this paper .
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TL;DR: The metabolic signatures observed in PC, a disease with a multifaceted and often transient metabolic landscape, are discussed, providing examples of how they could present novel targets for therapeutic interventions and elaborating on how interactions between the various cell types affect their metabolism.
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Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma -a systematic review and meta-analysis.
Stefania Bunduc,Noémi Gede,Szilárd Váncsa,Veronika Lillik,Szabolcs Kiss,Márk Juhász,Bálint Erőss,Zsolt Szakács,Cristian Gheorghe,Alexandra Mikó,Péter Hegyi +10 more
TL;DR: A systematic review and meta-analysis on the prognostic value of exosomal biomarkers in pancreatic ductal adenocarcinoma (PDAC) was performed in this paper .
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Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus
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Molecular Docking and Intracellular Translocation of Extracellular Vesicles for Efficient Drug Delivery
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TL;DR: It is shown that an efficient drug-delivery system and a useful therapeutic strategy can be established by controlling the molecular docking and intracellular translocation of exosomes.
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