Journal ArticleDOI
Partition coefficients of amino acids and hydrophobic parameters π of their side-chains as measured by thin-layer chromatography☆
TLDR
Partition coefficients in n-octanol-water have been determined for the naturally occurring and some synthetic α-amino acids using thin-layer chromatography in different solvent systems as discussed by the authors.About:
This article is published in Journal of Chromatography A.The article was published on 1981-10-30. It has received 99 citations till now. The article focuses on the topics: Partition coefficient & Thin-layer chromatography.read more
Citations
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Journal ArticleDOI
Amphipathic alpha helical antimicrobial peptides.
TL;DR: The simple guidelines obtained in this study allowed the design of highly active shortened AMPs and may be generally useful in the development of this type of peptides as anti-infective agents.
Journal ArticleDOI
Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein–Ligand Binding
Vijay M. Krishnamurthy,George K. Kaufman,Adam R. Urbach,Irina Gitlin,Katherine L. Gudiksen,Douglas B. Weibel,George M. Whitesides +6 more
TL;DR: Carbonic anhydrase is a protein that is especially well-suited to serve as a model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of inhibitor design, and medicinal chemistry.
Journal ArticleDOI
Almost all about citrulline in mammals.
Emmanuel Curis,Ioannis Nicolis,Christophe Moinard,S. Osowska,Naima Zerrouk,Simone Bénazeth,L. Cynober +6 more
TL;DR: One of the most promising research directions deals with the administration of citrulline as a more efficient alternative to arginine, especially against underlying splanchnic sequestration of amino acids.
Journal ArticleDOI
Development of hydrophobicity parameters to analyze proteins which bear post- or cotranslational modifications.
Shaun D. Black,Diane R. Mould +1 more
TL;DR: The comprehensive parameter set determined here greatly extends the ability to analyze homology, membrane directedness, and folding potential of proteins.
Journal ArticleDOI
Amino acid side chain parameters for correlation studies in biology and pharmacology.
TL;DR: Fifteen physicochemical descriptors of side chains of the 20 natural and of 26 non-coded amino acids are compiled and simple methods for their evaluation described and it is shown that three principal components account for 66% of the total variance in the available set.
References
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Journal ArticleDOI
Partition coefficients and their uses
Journal ArticleDOI
The significance of the difference between two means when the population variances are unequal
Journal ArticleDOI
Sample Criteria for Testing Outlying Observations
TL;DR: In this article, the significance of the largest observation in a sample of size $n$ from a normal population was investigated and the authors proposed a new statistic, S^2_n/S^2, to test whether the two largest observations are too large.
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