Journal ArticleDOI
Pathogenesis of Mycosis fungoides
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TLDR
In recent years genetic analyses have uncovered various chromosomal aberrations in the tumour cells of mycosis fungoides that relevance to the pathogenesis and clinical appearance are discussed.Abstract:
Summary Mycosis fungoides is the most common type of primary cutaneous lymphomas. The phenotype of the tumor cell corresponds to an effector/memorytype of helper T cell which, given its repertoire of homing receptors, is specialized for recirculation through the skin. In recent years genetic analyses have uncovered various chromosomal aberrations in the tumour cells of mycosis fungoides. Their relevance to the pathogenesis and clinical appearance are discussed in the following.read more
Citations
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Journal ArticleDOI
Whole genome sequencing reveals oncogenic mutations in mycosis fungoides
Laura Y. McGirt,Peilin Jia,Devin A. Baerenwald,Robert Duszynski,Kimberly B. Dahlman,John A. Zic,Jeffrey P. Zwerner,Donald Hucks,Utpal P. Davé,Zhongming Zhao,Christine M. Eischen +10 more
TL;DR: Genetic alterations in specific pathways in MF were identified that may be viable, effective new targets for treatment and identified 2 other potential contributing factors to MF, ultraviolet light, and a polymorphism in the tumor suppressor p53.
Journal ArticleDOI
Oncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome
Remco van Doorn,Marloes S. van Kester,Remco Dijkman,Maarten H. Vermeer,Aat A. Mulder,Karoly Szuhai,Jeroen Knijnenburg,Judith M. Boer,Rein Willemze,Cornelis P. Tensen +9 more
TL;DR: Genetic differences between MF and Sz suggest that the molecular pathogenesis and therefore therapeutic requirements of these cutaneous T-cell lymphomas may be distinct, and novel insight into genetic alterations underlying MF is provided.
Journal ArticleDOI
TH2 Cytokines from Malignant Cells Suppress TH1 Responses and Enforce a Global TH2 Bias in Leukemic Cutaneous T-cell Lymphoma
Emmanuella Guenova,Rei Watanabe,Jessica E. Teague,Jennifer A. DeSimone,Ying Jiang,Mitra Dowlatshahi,Christoph Schlapbach,Knut Schaekel,Alain H. Rook,Marianne Tawa,David C. Fisher,Thomas S. Kupper,Rachael A. Clark +12 more
TL;DR: The results suggest that therapies that inhibit TH2 cytokine activity, by virtue of their ability to improve TH1 responses, may have the potential to enhance both anticancer and antipathogen responses.
Journal ArticleDOI
Evolving Insights in the Pathogenesis and Therapy of Cutaneous T-cell lymphoma (Mycosis Fungoides and Sezary Syndrome)
TL;DR: A better understanding of the cell biology, immunology and genetics underlying the development and progression of CTCL will allow the design of more rational treatment strategies for these malignancies.
Journal ArticleDOI
Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma
Magdalena B. Wozniak,Raquel Villuendas,James R. Bischoff,Carmen Blanco Aparicio,Juan F. M. Leal,Paloma de la Cueva,Ma Elena Rodriguez,Beatriz Herreros,Daniel Martín-Pérez,María Isabel Longo,Marta Herrera,Miguel A. Piris,Pablo L. Ortiz-Romero +12 more
TL;DR: The functional analysis suggests that vorinostat modifies signaling of T-cell receptor, MAPK, and JAK-STAT pathways and shows that combination therapies involving histone deacetylase inhibitors and inhibitors of PI3K are potentially efficacious for the treatment of cutaneous T- cell lymphoma.
References
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Journal ArticleDOI
WHO-EORTC classification for cutaneous lymphomas.
Rein Willemze,Elaine S. Jaffe,Günter Burg,Lorenzo Cerroni,Emilio Berti,Steven H. Swerdlow,Elisabeth Ralfkiaer,Sergio Chimenti,José Luis Diaz-Perez,Lyn M. Duncan,Florent Grange,Nancy L. Harris,Werner Kempf,Helmut Kerl,Michael O. Kurrer,Robert Knobler,Nicola Pimpinelli,Chris Sander,Marco Santucci,Wolfram Sterry,Maarten H. Vermeer,Janine Wechsler,Sean Whittaker,Chris J.L.M. Meijer +23 more
TL;DR: The characteristic features of the different primary cutaneous lymphomas and other hematologic neoplasms frequently presenting in the skin are described, and differences with the previous classification schemes are discussed.
Journal ArticleDOI
Immunosuppressive Strategies that are Mediated by Tumor Cells
TL;DR: Different strategies employed by tumors to thwart immune responses, including tumor-induced impairment of antigen presentation, the activation of negative costimulatory signals, and the elaboration of immunosuppressive factors are discussed.
Journal ArticleDOI
Homeostasis of naive and memory T cells.
Charles D. Surh,Jonathan Sprent +1 more
TL;DR: This review highlights recent advances in how naive and memory T cell homeostasis is regulated.
Journal ArticleDOI
Disruption of the ARF–Mdm2–p53 tumor suppressor pathway in Myc-induced lymphomagenesis
TL;DR: It is reported that p53 and ARF also potentiate Myc-induced apoptosis in primary pre-B-cell cultures, and that spontaneous inactivation of the ARF-Mdm2-p53 pathway occurs frequently in tumors arising in Emu-myc transgenic mice.
Journal ArticleDOI
Sézary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors
TL;DR: The phenotype of T cells from L-CTCL and MF is studied to suggest that SS is a malignancy of central memory T cells and MF are a malIGNancy of skin resident effector memory T Cells.