Journal ArticleDOI
Pathology and genetics: Tumours of the digestive system
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This article is published in Surgical Oncology-oxford.The article was published on 2000-11-01. It has received 543 citations till now. The article focuses on the topics: Gastrointestinal pathology.read more
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Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis.
Hugo De Vuyst,Gary M. Clifford,Maria Claudia Nascimento,Margaret M. Madeleine,Silvia Franceschi +4 more
TL;DR: In conclusion, ∼40% of vulvar, 60% of vaginal and 80% of anal carcinoma may be avoided by prophylactic vaccines against HPV16/18, and this proportion would be similar for the corresponding high‐grade lesions of the vagina and anus, but higher for VIN2/3 than for vulvar carcinoma.
Journal ArticleDOI
BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
Takeshi Kambara,Lisa A. Simms,Vicki L. J. Whitehall,Kevin J. Spring,Coral V. A. Wynter,Michael Walsh,Melissa A. Barker,Sven Arnold,A McGivern,Nagahide Matsubara,Noriaki Tanaka,T Higuchi,Joanne P. Young,Jeremy R. Jass,Barbara A. Leggett +14 more
TL;DR: The BRAF mutation was frequently seen in SSA and in sporadic MSI-H CRC, both of which were associated with DNA methylation.
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Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus
Oliver Pech,Angelika Behrens,Andrea May,Lars Nachbar,Liebwin Gossner,Thomas Rabenstein,Hendrik Manner,Erwin Guenter,J. Huijsmans,Michael Vieth,Manfred Stolte,Christian Ell +11 more
TL;DR: This study showed that endoscopic therapy was highly effective and safe, with an excellent long-term survival rate, and the risk factors identified may help stratify patients who are at risk for recurrence and those requiring more intensified follow-up.
Journal ArticleDOI
Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults.
Roy Soetikno,Tonya Kaltenbach,Robert V. Rouse,Walter G. Park,Anamika Maheshwari,Tohru Sato,Suzanne Matsui,Shai Friedland +7 more
TL;DR: In this group of veteran patients, NP-CRNs were relatively common lesions diagnosed during routine colonoscopy and had a greater association with carcinoma compared with polypoid neoplasms, irrespective of size.
References
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Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
p53, the Cellular Gatekeeper for Growth and Division
TL;DR: The author regrets the lack of citations for many important observations mentioned in the text, but their omission is made necessary by restrictions in the preparation of review manuscripts.
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Genetic alterations during colorectal-tumor development.
Bert Vogelstein,Eric R. Fearon,Stanley R. Hamilton,Scott E. Kern,Ann C. Preisinger,Mark Leppert,A M Smits,Johannes L. Bos +7 more
TL;DR: It is found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas, which are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumors.
Journal ArticleDOI
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Yuan Chang,Ethel Cesarman,Melissa S. Pessin,Frank Lee,Janice Culpepper,Daniel M. Knowles,Patrick S. Moore +6 more
TL;DR: unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.