Pediatric, elderly, and emerging adult‐onset peaks in Burkitt's lymphoma incidence diagnosed in four continents, excluding Africa
Sam M. Mbulaiteye,William F. Anderson,Jacques Ferlay,Kishor Bhatia,Cindy M. Chang,Philip S. Rosenberg,Susan S. Devesa,Donald Maxwell Parkin +7 more
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TLDR
The hypothesis that BL is multimodal and that BL peaks at different ages may be clues to differences in the etiology and/or biology of BL at those ages is supported.Abstract:
Burkitt's lymphoma (BL) in the general population and immunosuppressed persons with AIDS in the United States was characterized by three age-specific incidence peaks near 10, 40, and 70 years. We hypothesized that BL from different geographical areas may exhibit pediatric, adult, and elderly age incidence peaks. We investigated this hypothesis using data on 3,403 cases obtained from the International Agency for Research on Cancer (1963-2002). Data from Africa were sparse or incomplete, and thus were excluded. Age-standardized rates (ASRs) and age-specific incidence rates were calculated, supplemented with the calculations performed using age-period-cohort (APC) models. The ASR rose 5.3% (95% confidence interval [CI], 5.0-5.6) per year in males and 4.6% (95% CI, 4.5-4.8) in females. The ASR increased gradually in children, steeply in adults and most rapidly in the elderly both in males and in females. Overall, BL male/female ASR ratio was 2.5, but it declined from 3.1 (95% CI, 3.0-3.3) for pediatric BL to 2.3 (95% CI, 2.2-2.4) for adult BL and 1.5 (95% CI, 1.4-1.6) for elderly BL. Age-specific incidence peaks occurred near 10 and 70 years in all regions and periods. A peak near 40 years of age emerged in the mid-1990s, particularly in men. Findings using APC models confirmed those based on the standard analyses. Our findings, based on the international BL cases, support our hypothesis that BL is multimodal and that BL peaks at different ages may be clues to differences in the etiology and/or biology of BL at those ages.read more
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Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and burkitt lymphoma
Richard A. Noble,Natalie Bell,Helen J. Blair,A Sikka,Huw D. Thomas,Nicole Phillips,Sirintra Nakjang,Satomi Miwa,Rachel E Crossland,Despina Televantou,Anna Long,Hector C. Keun,Chris M. Bacon,Simon Bomken,Susan E. Critchlow +14 more
TL;DR: Clinical examination of AZD3965 in Burkitt lymphoma and diffuse large B-cell lymphoma patients with low tumor monocarboxylate transporter 4 expression supports clinical examination and highlights the potential of combination strategies to optimally target the metabolic phenotype of tumors.
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Age-Period-Cohort Analysis of Stroke Mortality in China: Data From the Global Burden of Disease Study 2013
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International long‐term trends and recent patterns in the incidence of leukemias and lymphomas among children and adolescents ages 0–19 years
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TL;DR: Age‐specific patterns differed among the four hematopoietic malignancies, but were generally consistent within major categories world‐wide, except for non‐Hodgkin lymphoma.
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Lymphoid neoplasm incidence by WHO subtype in Australia 1982-2006.
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Burkitt lymphoma in adolescents and young adults: management challenges
Massimo Dozzo,Francesca Carobolante,Pietro Maria Donisi,Annamaria Scattolin,Elena Maino,Rosaria Sancetta,Piera Viero,Renato Bassan +7 more
TL;DR: The challenges ahead concern the following: optimization of management in underdeveloped countries, with reduction of diagnostic and referral-for-care intervals, and the applicability of currently curative regimens; the development of lower intensity but equally effective treatments for frail or immunocompromised patients at risk of death by complications; the identification of very high-risk patients through positron-emission tomography and minimal residual disease assays.
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Molecular diagnosis of Burkitt's lymphoma.
Sandeep S. Dave,Kai Fu,George E. Wright,Lloyd T. Lam,Philip M. Kluin,Evert Jan Boerma,Timothy C. Greiner,Dennis D. Weisenburger,Andreas Rosenwald,German Ott,Hans Konrad Müller-Hermelink,Randy D. Gascoyne,Jan Delabie,Lisa M. Rimsza,Rita M. Braziel,Thomas M. Grogan,Elias Campo,Elaine S. Jaffe,Bhavana J. Dave,Warren G. Sanger,Martin Bast,Julie M. Vose,James O. Armitage,Joseph M. Connors,Erlend B. Smeland,Stein Kvaløy,Harald Holte,Richard I. Fisher,Thomas P. Miller,Emilio Montserrat,Wyndham H. Wilson,Manisha Bahl,Hong Zhao,Liming Yang,John Powell,Richard M. Simon,Wing C. Chan,Louis M. Staudt +37 more
TL;DR: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma and the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens.
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