Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets.
Andrew S. Greenberg,John J. Egan,Sheree A. Wek,N B Garty,E J Blanchette-Mackie,Constantine Londos +5 more
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TLDR
Investigation of the lipid fraction of rat epididymal adipocytes suggests that perilipin plays a role in the specialized lipid storage function of adipocytes, and Immunocytochemical studies with specific antiserum shows that the perilipIn is closely associated with the periphery of lipid storage droplets in cultured adipocytes.About:
This article is published in Journal of Biological Chemistry.The article was published on 1991-06-15 and is currently open access. It has received 776 citations till now. The article focuses on the topics: Perilipin & Perilipin-1.read more
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Developmental Origin of Fat: Tracking Obesity to Its Source
TL;DR: This Review considers how the developmental origins of fat contribute to its physiological, cellular, and molecular heterogeneity and explores how these factors may play a role in the growing epidemic of obesity.
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Lipid Droplets and Cellular Lipid Metabolism
TL;DR: The current knowledge of LD cell biology and its translation to physiology is reviewed, finding that many aspects of LD biology are unknown.
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Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis.
TL;DR: A model is discussed whereby perilipin serves as a dynamic scaffold to coordinate the access of enzymes to the lipid droplet in a manner that is responsive to the metabolic status of the adipocyte.
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Enzymes of triacylglycerol synthesis and their regulation
TL;DR: De novo biosynthesis of triacylglycerol in eukaryotic cells, the isoenzymes that are involved, their subcellular locations, how they are regulated, and their putative individual roles in glycerolipid biosynthesis are focused on.
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Role of Caveolae and Caveolins in Health and Disease
TL;DR: The mechanisms by which caveolae and caveolins participate in human disease processes are provided, including diabetes, cancer, cardiovascular disease, atherosclerosis, pulmonary fibrosis, and a variety of degenerative muscular dystrophies.
References
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TL;DR: The early stages of absorption of intravenously injected horseradish peroxidase in proximal tubules of mouse kidney were studied with a new ultrastructural cytochemical technique, which gives sharp localization and is sensitive to protein transport.
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A simple method of reducing the fading of immunofluorescence during microscopy
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An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion
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Intermediate Filaments: A Chemically Heterogeneous, Developmentally Regulated Class of Proteins
TL;DR: Descmin Filaments: Integration oj Myojibrils at the Z Disc explores the role of keratin Filaments in the integration of proteins and their role in wound healing.