Journal ArticleDOI
Pharmaceutical Amorphous Nanoparticles.
Rajan Jog,Diane J. Burgess +1 more
TLDR
An example of this technology is NanomorphTM, developed by Soliqus/Abbott, wherein the nanosize drug particles are precipitated in an amorphous form in order to enhance the dissolution rate.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 2017-01-01. It has received 110 citations till now. The article focuses on the topics: Amorphous solid.read more
Citations
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Journal ArticleDOI
Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
TL;DR: The brief history of the field is surveyed from a drug discovery perspective with a focus on the key advances in knowledge which have led to the definition and exemplification of protein degradation concepts and their resulting applications to medicine discovery.
Journal ArticleDOI
Pharmaceutical nanocrystals: production by wet milling and applications.
Maria Malamatari,Maria Malamatari,Kevin M.G. Taylor,Stavros Malamataris,Dennis Douroumis,Kyriakos Kachrimanis +5 more
TL;DR: The features, preparation methods, and therapeutic applications of pharmaceutical nanocrystals are summarized and discussed, highlighting their universality as a formulation approach for poorly soluble drugs.
Journal ArticleDOI
Enhancement of Curcumin Bioavailability by Encapsulation in Sophorolipid-Coated Nanoparticles: An in Vitro and in Vivo Study
TL;DR: Both in vitro and in vivo studies showed that the curcumin nanoparticles had an appreciably higher bioavailability than that of freeCurcumin crystals (2.7-3.6-fold), which was mainly attributed to their higher bioaccessibility.
Journal ArticleDOI
Improving curcumin solubility and bioavailability by encapsulation in saponin-coated curcumin nanoparticles prepared using a simple pH-driven loading method.
TL;DR: All-natural colloidal delivery systems were developed to overcome challenges of low water-solubility, chemical instability, and poor oral bioavailability of curcumin, which consisted of saponin-coatedCurcumin nanoparticles formed using a pH-driven loading method.
Journal ArticleDOI
The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications.
TL;DR: A critical summary of the synthesis and applications of PLGA-based systems in bio-medicine is provided and experimental and computational design considerations of these systems are outlined.
References
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Journal ArticleDOI
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
TL;DR: Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described in this article, where the rule of 5 is used to predict poor absorption or permeability when there are more than 5 H-bond donors, 10 Hbond acceptors, and the calculated Log P (CLogP) is greater than 5 (or MlogP > 415).
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Drug-like properties and the causes of poor solubility and poor permeability
TL;DR: There are currently about 10000 drug-like compounds, and true diversity does not exist in experimental combinatorial chemistry screening libraries because current ADME experimental screens are multi-mechanisms, and predictions get worse as more data accumulates.
Journal ArticleDOI
Improving drug solubility for oral delivery using solid dispersions.
TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.
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Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
TL;DR: Commercial use of solid dispersion systems during the past four decades has been very limited, primarily because of manufacturing difficulties and stability problems, but this has been changing in recent years because of the availability of surface-active and self-emulsifying carriers and the development of technologies to encapsulate solid dispersions directly into hard gelatin capsules as melts.
Journal ArticleDOI
What is the true solubility advantage for amorphous pharmaceuticals
Bruno C. Hancock,Michael Parks +1 more
TL;DR: Amorphous pharmaceuticals are markedly more soluble than their crystalline counterparts, however, their experimental solubility advantage is typically less than that predicted from simplethermodynamic considerations.