Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion
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PH via TRPV1 agonist appears to be a well-tolerated and effective method for promoting mild hypothermia in the conscious mouse and significantly improves outcome when initiated 90 min after start of reperfusion.Abstract:
Traditional methods of therapeutic hypothermia show promise for neuroprotection against cerebral ischemia-reperfusion (I/R), however, with limitations We examined effectiveness and specificity of read more
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Peripheral thermosensation in mammals
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Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here.
Matthew K. Tobin,Jacqueline A. Bonds,Richard D. Minshall,Dale A. Pelligrino,Fernando D. Testai,Orly Lazarov +5 more
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Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory
Adchara Janyou,Piyawadee Wicha,Jinatta Jittiwat,Apichart Suksamrarn,Chainarong Tocharus,Jiraporn Tocharus +5 more
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Still cooling after all these years: Meta-analysis of pre-clinical trials of therapeutic hypothermia for acute ischemic stroke.
TL;DR: Using several outcome measures in a variety of models and species, therapeutic hypothermia was protective compared with normothermia, with powerful and statistically significant normalized treatment effect sizes, in 60 papers comprising 216 comparisons.
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The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System
TL;DR: The function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, are explained and the intrinsic relationship between the expression and function of TRpV1 in those diseases is investigated to find new therapeutic targets for the cure of related diseases.
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TL;DR: It is shown that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP), which indicates that the vanilloid receptor may be another molecular target for endogenousAnandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
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Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury
Raul Busto,W. Dalton Dietrich,Mordecai Y.-T. Globus,I. Valdes,Peritz Scheinberg,Myron D. Ginsberg +5 more
TL;DR: Results demonstrate that rectal temperature unreliably reflects brain temperature during ischemia, and that despite severe depletion of brain energy metabolites at all temperatures, small increments of intraischemic brain temperature markedly accentuate histopathological changes following 3-day survival.
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Neurological Deficit and Extent of Neuronal Necrosis Attributable to Middle Cerebral Artery Occlusion in Rats Statistical Validation
TL;DR: The histological effects of an intracranial arterial occlusion in the adult rat can be predicted on day 1 by the neurological score described in this report, and significant improvement can be obtained in these animals by reestablishing arterial flow 60 minutes or sooner after the ictus.
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Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
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