Proceedings ArticleDOI
PhoneQuant: A smartphone-based quantitative immunoassay analyser
Malay Ilesh Shah,Jayaraj Joseph,Ujwal Sriharsha Sanne,Mohanasankar Sivaprakasam +3 more
- Vol. 2017, pp 4247-4250
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TLDR
The PhoneQuant analyser is the portable cost-effective solution to traditional bulky LFIA analysers and it has good potential to be deployed at physician's desk or for in-home PoC testing for quick and reliable diagnosis.Abstract:
There is a vital need for portable and cost-effective point-of-care (PoC) testing technologies that provide reliable and rapid results. Lateral Flow Immunoassays (LFIA) are suitable PoC diagnostic tools with the potential for use in a wide variety of field applications ranging from uses in clinical diagnostics to aiding law enforcement. Quick and reliable diagnosis of non-communicable diseases (NCD) like diabetes is vital especially in developing countries like India where the burden of these diseases is very high and is increasing day by day. In this paper, we have presented the design of smartphone-based fully quantitative LFIA analyser, An automatic image processing algorithm is also described. A repeatability study was done with stable fluorescence reference cartridges. The Coefficient of Variation (CoV) for repeatability study was calculated and it was found to be good (< 1.5%). The instrument was tested with blood samples to generate a calibration curve for Glycated Haemoglobin (HbA1c) with respect to standard lab instrument. Three different set of settings parameters were used in smartphone camera their calibration curve formed. All three curves were linearly correlated with R2-value greater than 0.985. Finally, the calibration curve was validated through three HbA1c blood sample tests- for each sample, CoV was less than 5%. The PhoneQuant analyser is the portable cost-effective solution to traditional bulky LFIA analysers and it has good potential to be deployed at physician's desk or for in-home PoC testing for quick and reliable diagnosis.read more
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Journal ArticleDOI
Development of Smartphone-Based Lateral Flow Device for the Quantification of LH and E3G Hormones
Ritambhara Thakur,Faiz Akram,Vivek Rastogi,Amit Mitra,Rahul Nawani,Varun Av,Satish Kumar Dubey,Chandra Shakher +7 more
TL;DR: The proposed Inito device can be very useful in point of care (PoC) settings and is coupled to a smartphone to predict the fertile window by providing a precise estimation of the concentration of these hormones.
Proceedings ArticleDOI
Multi-cartridge Fluorescence Reader for Quantitative Immunoassays
TL;DR: A camera based multi-cartridge fluorescence reader that can carry out simultaneous analysis of four LFIA test cartridges and is a simple, rugged system requiring minimal human intervention and the average time taken for tests is lower as compared to the available LFIA readers.
Journal ArticleDOI
Assessment of Immune Status Using Inexpensive Cytokines: A Literature Review and Learning Approaches
Noor Jamaludeen,J. Lehmann,Christian Beyer,Katrin Vogel,Mandy Pierau,Monika C. Brunner-Weinzierl,Myra Spiliopoulou +6 more
TL;DR: In this article , the authors investigate the current development of point-of-care (POC) technologies suitable for the home testing of cytokines by conducting a PRISMA literature review.
References
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Lateral flow immunoassay
Raphael C. Wong,Harley Y. Tse +1 more
TL;DR: Manufacturing the Next Generation of Highly Sensitive and Reproducible Lateral Flow Immunoassay Tests and Quantitative, False Positive, and False Negative Issues for Lateral flow immunoassays as Exemplified by Onsite Drug Screens are studied.
Journal ArticleDOI
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TL;DR: This report aims to review recent developments in CBDs for bioanalytical sciences along with some of the challenges involved and the future opportunities.