Journal ArticleDOI
Plasma abnormal prothrombin (Des-γ-carboxy prothrombin) as a marker of hepatocellular carcinoma
TLDR
The results suggested strongly that DCP was synthesized by the hepatoma cells as a serologic marker for hepatocellular carcinoma.Abstract:
Des-gamma-carboxy prothrombin [DCP], a protein induced by vitamin K absence or antagonist-II and also abbreviated PIVKA-II, was evaluated as a serologic marker for hepatocellular carcinoma (HCC). Its plasma levels were measured by enzyme immunoassay (E-1023) using an anti-DCP monoclonal antibody in 514 patients with various diseases. Of 120 patients with HCC, 76 (63%) had abnormal DCP levels greater than 0.1 arbitrary unit (AU)/ml and 58 (48%) showed levels greater than 0.3 AU/ml. When a diagnostic minimum level of 0.3 AU/ml was applied for DCP, false-positive cases of HCC were virtually eliminated. In some patients with HCC, plasma DCP levels normalized after surgical resection of the tumor. However, they rose again later with recurrence of the disease. The sensitivity of DCP in the diagnosis and monitoring of HCC was increased by serial and simultaneous determinations of alpha-fetoprotein (AFP), because high DCP levels were observed more often in low AFP-producing HCC patients. Elevated plasma DCP levels were not related to low vitamin K concentration in the serum. In fact, in many patients vitamin K administration resulted in only a moderate reduction of DCP levels. These results suggested strongly that DCP was synthesized by the hepatoma cells.read more
Citations
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Diagnosis and Monitoring of Hepatic Injury. II. Recommendations for Use of Laboratory Tests in Screening, Diagnosis, and Monitoring
D. Robert Dufour,John A. Lott,Frederick S. Nolte,David R. Gretch,Raymond S. Koff,Leonard B. Seeff +5 more
TL;DR: Although ALT is useful for detecting acute and chronic hepatic injury, it is not related to severity of acute Hepatitis B and C and only weakly related to severe severity of chronic hepatics injury.
Journal ArticleDOI
Prospective study of α-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma
TL;DR: Patients who had α‐fetoprotein levels of 20 ng/ml or more, who had transient increases in α‐ Fetoprotein or who had both should be treated as being in a super‐high‐risk group for hepatocellular carcinoma, according to a prospective study of 260 patients with cirrhosis.
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A Collaborative Study for the Evaluation of Lectin-Reactive α-Fetoproteins in Early Detection of Hepatocellular Carcinoma
Kazuhisa Taketa,Yasuo Endo,Chihiro Sekiya,Kyuichi Tanikawa,Toshihiko Koji,Hiroko Taga,Shinji Satomura,Shuji Matsuura,Tadashi Kawai,Hidematsu Hirai +9 more
TL;DR: These tests are useful for the early detection of hepatocellular carcinomas in patients with hepatitis or liver cirrhosis by imaging techniques with a sensitivity and specificity of 48% and 81%.
Journal ArticleDOI
Fibrolamellar Hepatocellular Carcinoma: Imaging and Pathologic Findings in 31 Recent Cases
Tomoaki Ichikawa,Michael P. Federle,Luigi Grazioli,Juan Madariaga,Michael A. Nalesnik,Wallis Marsh +5 more
TL;DR: CT and MR images demonstrate characteristic features that may allow confident diagnosis of fibrolamellar HCC, and calcifications were depicted as hypointense to surrounding tumor in nine cases.
Journal ArticleDOI
Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update.
Masatoshi Kudo,Yusuke Kawamura,Kiyoshi Hasegawa,Ryosuke Tateishi,Kazuya Kariyama,Shuichiro Shiina,Hidenori Toyoda,Yasuharu Imai,Atsushi Hiraoka,Masafumi Ikeda,Namiki Izumi,Michihisa Moriguchi,Sadahisa Ogasawara,Yasunori Minami,Kazuomi Ueshima,Takamichi Murakami,Shiro Miyayama,Osamu Nakashima,Hirohisa Yano,Michiie Sakamoto,Etsuro Hatano,Mitsuo Shimada,Norihiro Kokudo,Satoshi Mochida,Tetsuo Takehara +24 more
TL;DR: The Clinical Practice Manual for Hepatocellular Carcinoma (HCC) as mentioned in this paper was published by the Japan Society of Hepatology (JSH) expert panel in 2007, with emphasis on the consensus statements and recommendations for the management of HCC.
References
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TL;DR: The method utilizes the difference between the rate of electrophoretic migration of proteins and of their antibody complexes in agarose gel to perform quantitative analysis of proteins with a charge differing from that of the bulk of the immunoglobulins.
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Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report
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Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis: A prospective study
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Journal ArticleDOI
Diagnosis and Clinical Features of Small Hepatocellular Carcinoma With Emphasis on the Utility of Real-Time Ultrasonography: A Study in 51 Patients
Takashi Shinagawa,Masao Onto,Kunio Kimura,Shigeyuki Tsunetomi,Masahiko Morita,Hiromitsu Saisho,Yukihiro Tsuchiya,Naoki Saotome,Eii Karasawa,Makoto Miki,T. Ueno,Kunio Okuda +11 more
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