Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome.
Xiaomin Zhang,Zengguang Xu,Li Zhou,Ying Chen,Meian He,Longxian Cheng,Frank B. Hu,Robert M. Tanguay,Tangchun Wu +8 more
TLDR
It is suggested that higher Hsp70 levels or lower anti-Hsp70 antibody levels are independently associated with a higher risk of acute coronary syndrome (ACS) and lower levels combine to further increase this risk.Abstract:
Although immune reactions against heat shock proteins have been implicated in the pathogenesis of atherosclerosis, conflicting associations between Hsp70, anti-Hsp70 antibody and coronary heart disease (CHD) have been reported. This study assessed whether there is a significant association between extracellular human Hsp70, anti-Hsp70 antibody and acute coronary syndrome (ACS) and stable angina (SA), and examined dynamic changes in Hsp70 and anti-Hsp70 antibody levels induced by acute myocardial infarction (AMI). Plasma Hsp70 and anti-Hsp70 antibody levels in 291 patients with ACS (179 AMI, 112 unstable angina), 126 patients with SA and 417 age and sex-matched healthy subjects, and in 40 patients after admission for AMI, and on day 2, 3, and 7 after the onset of AMI were determined using enzyme-linked immunosorbent assays. Hsp70 levels were significantly higher in ACS and SA and anti-Hsp70 antibody levels were only markedly lower in ACS than controls. After adjustment for traditional CHD risk factors, increasing levels of Hsp70 were significantly associated with an increased risk and severity of ACS (P for trend < 0.001), whereas increasing levels of anti-Hsp70 antibody were associated with a decreased risk of ACS (P for trend = 0.0003). High levels of Hsp70 combined with low levels of anti-Hsp70 antibody had a joint effect on the risk of ACS (OR, 5.14, 95% CI, 3.00-8.79; P < 0.0001). In patients with AMI, Hsp70 levels decreased rapidly from days 1-7 after onset, whereas anti-Hsp70 antibody levels increased in patients with AMI. These findings suggest that higher Hsp70 levels or lower anti-Hsp70 antibody levels are independently associated with a higher risk of ACS. Higher Hsp70 levels and lower anti-Hsp70 antibody levels combine to further increase this risk.read more
Citations
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Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa.
TL;DR: The term Stress Observation System (SOS) is coined for the mechanism for sensing extracellular hsp, which is a form of cellular communication during stress conditions and which is likely to act as indicators of the stress conditions, priming other cells to avoid the propagation of the insult.
Journal ArticleDOI
Extracellular heat shock proteins: a new location, a new function.
Antonio De Maio,Daniel Vazquez +1 more
TL;DR: Current knowledge about the release and relevance of extracellular HSPs is addressed, including translocation across the plasma membrane and release associated with lipid vesicles, as well as the passive release after cell death by necrosis.
Journal ArticleDOI
Aggregate risk score based on markers of inflammation, cell stress, and coagulation is an independent predictor of adverse cardiovascular outcomes.
Danny J. Eapen,Pankaj Manocha,Riyaz S. Patel,Riyaz S. Patel,Muhammad Hammadah,Emir Veledar,Christina L. Wassel,Ravi Nanjundappa,Sergey Sikora,Dylan Malayter,Peter W.F. Wilson,Laurence S. Sperling,Arshed A. Quyyumi,Stephen E. Epstein +13 more
TL;DR: An aggregate score based on serum levels of CRP, FDP, and HSP70 is a predictor of future risk of death and MI in patients with suspected or known CAD.
Journal ArticleDOI
Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: a review and comparison to other methods of detection in thoracic aneurysm repair
TL;DR: No other measurement appears to be of use in the immediate detection of ongoing severe ischemia with the intention to immediately intervene to reduce the severity or risk of permanent damage.
Journal ArticleDOI
Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis
J. Christopher States,Amar V. Singh,Amar V. Singh,Thomas B. Knudsen,Thomas B. Knudsen,Eric C. Rouchka,Ntube N. O. Ngalame,Ntube N. O. Ngalame,Gavin E. Arteel,Yulan Piao,Minoru S.H. Ko +10 more
TL;DR: The results suggest that transplacental arsenic exposure alters developmental programming in fetal liver, leading to an enduring stress and proinflammatory response postnatally that may contribute to early onset of atherosclerosis.
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