Journal ArticleDOI
Plasticizing effect of water on poly(lactide-co-glycolide).
TLDR
It is proposed that the water responsible for plasticizing the polymer was non-freezable (bound) water and the small fraction of such water which was absorbed at high relative humidity caused polymer degradation in the same manner as bulk water.About:
This article is published in Journal of Controlled Release.The article was published on 2005-11-02. It has received 260 citations till now. The article focuses on the topics: Differential scanning calorimetry & Water content.read more
Citations
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Journal ArticleDOI
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
Journal ArticleDOI
The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review.
TL;DR: This review provides a survey and analysis of the processes determining the release rate, and the various mechanisms of drug release that have been reported in the literature are analyzed in this review.
Journal ArticleDOI
Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles.
TL;DR: Against the backdrop of an increasing number of new, poorly orally available drug entities entering development, microparticle delivery systems may be a viable strategy to rescue an otherwise undeliverable substance.
Journal ArticleDOI
Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds.
TL;DR: The results suggest that fibrous scaffolds made of PGE and similar biomimetic blends of natural and synthetic polymers may be useful for engineering soft tissues, such as heart, lung, and blood vessels.
Journal ArticleDOI
Chemical degradation of peptides and proteins in PLGA: A review of reactions and mechanisms
TL;DR: This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms and the reported methods for stabilizing peptides and proteins inPLGA devices.
References
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Journal ArticleDOI
Synthetic biodegradable polymers as orthopedic devices.
John Middleton,Arthur J. Tipton +1 more
TL;DR: In this paper, the authors focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired, and an overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
TL;DR: A pH gradient is shown, with the most acidic environment at the center of the spheres and higher pH near the edges, which is characteristic of diffusion-controlled release of the acidicdegradation products.
Journal ArticleDOI
The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids.
Bruno C. Hancock,George Zografi +1 more
TL;DR: It was found that there is a rapid initial reduction in the glass transition temperature from the dry state as water is absorbed, followed by a gradual leveling off of the response at higher water contents, indicating that water acts as a plasticizer in a way similar to that of other small molecules and not through any specific or stoichiometric interaction process(es).
Journal ArticleDOI
Hydrolytic degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids.
TL;DR: This review presents the state of the art in this domain and an attempt is also made to elaborate a scheme that can be used to predict degradation characteristics of these polymers from their initial composition and morphology.
Journal ArticleDOI
In vitro degradation of three-dimensional porous poly(d,l-lactide-co-glycolide) scaffolds for tissue engineering
Linbo Wu,Jiandong Ding +1 more
TL;DR: In vitro degradation behaviors of three-dimensional tissue engineering porous scaffolds made from amorphous poly(D,L-lactide-co-glycolide) with three different formulations have been systematically investigated and the determination of mechanical properties in wet environment was of special interest.