Polarization and Movement of Keratocytes: A Multiscale Modelling Approach
Athanasius F. M. Marée,Alexandra Jilkine,Adriana T. Dawes,Verônica A. Grieneisen,Leah Edelstein-Keshet +4 more
TLDR
This model explains how a keratocyte cell can maintain its shape and polarity, even after removal of the initial stimulus, and how it can change direction quickly in response to changes in its environment.About:
This article is published in Bulletin of Mathematical Biology.The article was published on 2006-06-23 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Actin cytoskeleton & Arp2/3 complex.read more
Citations
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Wave-pinning and cell polarity from a bistable reaction-diffusion system.
TL;DR: The mathematical basis of the phenomenon is explained, it is related to spatial segregation of Rho GTPases, and it is shown how it can account for spatial amplification and maintenance of polarity, as well as sensitivity to new stimuli typical in polarization of eukaryotic cells.
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Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions
Melda Tozluoglu,Alexander L. Tournier,Robert P. Jenkins,Steven Hooper,Paul A. Bates,Erik Sahai +5 more
TL;DR: A model of cell motility that encompasses actin-polymerization-based protrusions, actomyosin contractility, variable actin–plasma membrane linkage leading to membrane blebbing, cell–extracellular-matrix adhesion and varying extracellular matrix geometries is presented.
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Navigating through models of chemotaxis.
TL;DR: The strengths and weaknesses of the proposed chemotaxis models are summarized and the need for an integrated model is pointed out.
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The Shape of Motile Cells
Alex Mogilner,Kinneret Keren +1 more
TL;DR: Focusing on several different cell types, including keratocytes and fibroblasts, this work discusses how dynamic cell morphology emerges from the interplay between the different motility modules and the environment.
References
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Equation of state calculations by fast computing machines
TL;DR: In this article, a modified Monte Carlo integration over configuration space is used to investigate the properties of a two-dimensional rigid-sphere system with a set of interacting individual molecules, and the results are compared to free volume equations of state and a four-term virial coefficient expansion.
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Rho GTPases and the Actin Cytoskeleton
TL;DR: Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
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Construction of a genetic toggle switch in Escherichia coli
TL;DR: The construction of a genetic toggle switch is presented—a synthetic, bistable gene-regulatory network—in Escherichia coli and a simple theory is provided that predicts the conditions necessary for bistability.
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Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Thomas D. Pollard,Gary G. Borisy +1 more
TL;DR: A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematical models of the constituent reactions predict the rate of motion.