Journal ArticleDOI
Poly (glutamic acid)--an emerging biopolymer of commercial interest.
Ishwar B. Bajaj,Rekha S. Singhal +1 more
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In this paper, the authors provide updated information on fermentative production of poly (γ-glutamic acid) by various bacterial strains and effect of fermentation conditions and media component on production of PGA in submerged as well as solid state fermentation.About:
This article is published in Bioresource Technology.The article was published on 2011-05-01. It has received 308 citations till now.read more
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pH-Sensitive nano-systems for drug delivery in cancer therapy
TL;DR: This review mainly focuses on pH-sensitive nano-systems, including advances in drug delivery, mechanisms of drug release, and possible improvements in drug absorption, with the emphasis on recent research in this field.
Journal ArticleDOI
Multicomponent peptide assemblies
TL;DR: The design, structure, emergent properties, and applications for these multicomponent assemblies are presented in order to illustrate the potential of these formulations as sophisticated next-generation bio-inspired materials.
Journal ArticleDOI
Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment.
TL;DR: Various responsive modes triggered by the tumor microenvironment stimuli are expatiated on, recent advances in multistage nanoparticle systems, especially the multi-stimuli responsive delivery systems are introduced, and their functions, effects, and prospects are discussed.
Journal ArticleDOI
Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non-traditional microorganisms.
Patricia Calero,Pablo I. Nikel +1 more
TL;DR: This review discusses the state of the art in the rational design and construction of robust bacterial chassis for metabolic engineering, presenting key examples of bacterial species that have secured a place in industrial bioproduction.
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Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review.
TL;DR: This review will focus on the potential of pH-sensitive micells in tumor therapy, analyze four types of drug-loaded micelles and mechanisms of drug release and give an exhaustive collection of recent investigations.
References
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Journal ArticleDOI
Adsorption of toxic mercury(II) by an extracellular biopolymer poly(γ-glutamic acid).
TL;DR: Adsorption of mercury(II) by an extracellular biopolymer, poly(gamma-glutamic acid) (Gamma-PGA), was studied as a function of pH, temperature, agitation time, ionic strength, light and heavy metal ions.
Journal ArticleDOI
Paclitaxel poliglumex (XYOTAX, CT-2103): a macromolecular taxane.
TL;DR: Preclinical studies in animal tumor models demonstrate that PPX is more effective than standard paclitaxel and is associated with prolonged tumor exposure to active drug while minimizing systemic exposure.
Journal ArticleDOI
Biosynthesis and Hydrolysis of Poly(γ-glutamic acid) from Bacillus subtilis IF03335
Atsuo Goto,Masao Kunioka +1 more
TL;DR: Hydrolytic degradation of PGA was found to proceed through a random chain scission and a by-product was produced, which seemed to be a polysaccharide.
Journal ArticleDOI
Empirical modeling of batch fermentation kinetics for poly(glutamic acid) production and other microbial biopolymers
TL;DR: An empirical kinetic model is proposed for the batch production of poly(glutamic acid) from Bacillus subtilis IFO 3335 and fits the experimental biomass data using a sigmoidal relationship that includes the maximum specific growth rate, μmax, and the substrate saturation parameter, KS.
Journal ArticleDOI
γ-Poly(glutamic acid) formation by Bacillus licheniformis 9945a: physiological and biochemical studies
TL;DR: Cryogenically frozen vegetative cells of Bacillus licheniformis 9945a derived from young mucoid colonies were used to inoculate production media containing l -glutamate, citrate and glycerol as carbon sources to suggest that γ-PGA depolymerase is intracellularly located or cell-bound.
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The production of poly-(γ-glutamic acid) from microorganisms and its various applications
Ing-Lung Shih,Yi-Tsong Van +1 more