Journal ArticleDOI
pH-Sensitive nano-systems for drug delivery in cancer therapy
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TLDR
This review mainly focuses on pH-sensitive nano-systems, including advances in drug delivery, mechanisms of drug release, and possible improvements in drug absorption, with the emphasis on recent research in this field.About:
This article is published in Biotechnology Advances.The article was published on 2014-07-01. It has received 837 citations till now. The article focuses on the topics: Targeted drug delivery & Drug delivery.read more
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Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Mahdi Karimi,Amir Ghasemi,Parham Sahandi Zangabad,Reza Rahighi,S. Masoud Moosavi Basri,S. Masoud Moosavi Basri,Hamed Mirshekari,Mandana Amiri,Z. Shafaei Pishabad,A. Aslani,Mahnaz Bozorgomid,Deepanjan Ghosh,Ali Beyzavi,A. Vaseghi,Amir Reza Aref,L. Haghani,Sajad Bahrami,Michael R. Hamblin,Michael R. Hamblin +18 more
TL;DR: This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.
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Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review.
TL;DR: P pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release, helping to design more efficient drug delivery systems.
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The Smart Drug Delivery System and Its Clinical Potential
TL;DR: The recent advances of smart nanoplatforms for targeting drug delivery, including stimuli-responsive polymeric nanoparticles, liposomes, metals/metal oxides, and exosomes are highlighted.
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Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment
TL;DR: This review article summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones, which it believes offer a good chance for the practical translation of nanoparticle formulas into clinic.
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Tumour acidosis: from the passenger to the driver's seat.
Cyril Corbet,Olivier Feron +1 more
TL;DR: The current understanding of how H+-generating metabolic processes segregate within tumours according to the distance from blood vessels is summarized and how ambient acidosis influences tumour metabolism, reducing glycolysis while promoting mitochondrial activity is summarized.
References
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Journal ArticleDOI
Emerging applications of stimuli-responsive polymer materials
Martien A. Cohen Stuart,Wilhelm T. S. Huck,Jan Genzer,Marcus Müller,Christopher K. Ober,Manfred Stamm,Gleb B. Sukhorukov,Igal Szleifer,Vladimir V. Tsukruk,Marek W. Urban,Françoise M. Winnik,Stefan Zauscher,Igor Luzinov,Sergiy Minko +13 more
TL;DR: This work reviews recent advances and challenges in the developments towards applications of stimuli-responsive polymeric materials that are self-assembled from nanostructured building blocks and provides a critical outline of emerging developments.
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Nanoparticles in Medicine: Therapeutic Applications and Developments
TL;DR: Nanomaterials have unique physicochemical properties, such as ultra small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials of the same composition, which can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents.
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Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
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Polymer conjugates as anticancer nanomedicines
TL;DR: There is growing optimism that ever more sophisticated polymer-based vectors will be a signficant addition to the armoury currently used for cancer therapy.
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Gold nanocages covered by smart polymers for controlled release with near-infrared light
Mustafa Selman Yavuz,Yiyun Cheng,Jingyi Chen,Claire M. Cobley,Qiang Zhang,Matthew Rycenga,Jingwei Xie,Chulhong Kim,Kwang H. Song,Andrea G. Schwartz,Lihong V. Wang,Younan Xia +11 more
TL;DR: This work develops a platform based on the photothermal effect of gold nanocages that works well with various effectors without involving sophiscated syntheses, and is well-suited for in vivo studies due to the high transparency of soft tissue in NIR.