Journal ArticleDOI
Polymer Microfabrication for Microarrays, Microreactors and Microfluidics
TLDR
In this paper, a hot embossing of polymer materials is used to produce stable and reproducible polymer microstructures with structural and optical properties meeting other biocompatibility and detection requirements for a wide range of microfabrication applications.Abstract:
Polymer microfabrication methods are becoming increasingly important as low-cost alternatives to the silicon or glass-based MEMS technologies. Polymer hot embossing and injection molding are replication methods applicable to microreplication of a diversity of materials and microstructures.Equipment with high precision control of pressure and temperature for hot embossing of polymer materials is now available commercially. These systems have made possible the replication of chips containing microchannels for capillary electrophoresis (CE) and microfluidics devices, microoptical components and microreactors. Stable and reproducible polymer microstructures have been demonstrated in several types of materials with structural and optical properties meeting other biocompatibility and detection requirements. The process involves few variable parameters and results in high structural accuracy suited for a wide range of microfabrication applications.After demonstrating equivalent and, in cases, improved performanc...read more
Citations
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Journal ArticleDOI
High sensitivity PCR assay in plastic micro reactors
Jianing Yang,Yingjie Liu,Cory B. Rauch,Rauch L Stevens,Randall H Liu,Robin Lenigk,Piotr Grodzinski +6 more
TL;DR: This is the first systematic study of assay sensitivity and specificity performed in plastic, disposable micro PCR devices, in amplification of Escherichia coli K12-specific gene fragment through multiplex PCR and/or amplification of different pathogen-specific genes.
Journal ArticleDOI
Comparison of ANN and DoE for the prediction of laser-machined micro-channel dimensions
TL;DR: Four models developed for the prediction of the width and depth dimensions of CO 2 laser-formed micro-channels in glass showed greater average percentage error than the DoE model, and one showed an improved predictive capability that was approximately twice as good as that provided from the doE model.
Journal ArticleDOI
Calcium alginate microcapsule generation on a microfluidic system fabricated using the optical disk process
TL;DR: In this article, the authors describe the generation of monodisperse calcium alginate (Ca-alginate) microcapsules on a microfluidic platform using the commercial optical disk process, which is based on combining the rapid injection molding process for a cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil emulsions.
Journal ArticleDOI
Microchannel Reactors: Applications and Use in Process Development
TL;DR: In this paper, a review of recent research results on micro-channel reactors is presented with particular reference to their applications and use as a cost effective tool during process development tasks, and a variety of applications to catalysis, polymers, advanced materials, biosystems, organic reaction etc.
Book ChapterDOI
Laser Micromachining for Transparent Materials
TL;DR: In this paper, the internal and surface laser micromachining processes in transparent media are presented, including laser power, wavelength, pulse duration, and repetition rate, and the operation conditions, such as distance from focus, sample speed, total irradiation duration and environment (gas, air, or vacuum).
References
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Journal ArticleDOI
Miniaturized total chemical analysis systems: A novel concept for chemical sensing
TL;DR: In this paper, a modular construction of a miniaturized "total chemical analysis system" is proposed, and theoretical performances of such systems based on flow injection analysis, chromatography and electrophoresis are compared with those of existing chemical sensors and analysis systems.
Book
Fundamentals of microfabrication
TL;DR: The second edition of the Fundamentals of Microfabrication as discussed by the authors provides an in-depth coverage of the science of miniaturization, its methods, and materials, from the fundamentals of lithography through bonding and packaging to quantum structures and molecular engineering.
Journal ArticleDOI
Microchannel electrophoretic separations of DNA in injection-molded plastic substrates
TL;DR: These devices could lead to the production of low-cost, single-use electrophoretic chips suitable for a variety of separation applications, including DNA sizing, DNA sequencing, random primary library screening, and rapid immunoassay testing.
Journal ArticleDOI
Fabrication of plastic microfluid channels by imprinting methods.
Larissa E. Martynova,Laurie E. Locascio,Michael Gaitan,Gary W. Kramer,Richard G. Christensen,William A. MacCrehan +5 more
TL;DR: Microfluidic devices have been fabricated on poly(methyl methacrylate) substrates by two independent imprinting techniques and fluorescent analtyes were used to demonstrate reproducible electrophoretic injections.