Journal ArticleDOI
Polymorphism T→C of gene CYP17 promoter and polycystic ovary syndrome risk: a meta-analysis.
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TLDR
This meta-analysis suggests that the CYP17 T/C polymorphism may be not associated with PCOS risk, while the observed increase in risk of PCOS may be due to small-study bias.About:
This article is published in Gene.The article was published on 2012-03-01. It has received 21 citations till now. The article focuses on the topics: Polycystic ovary.read more
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Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden.
Kyriaki Kosidou,Christina Dalman,Christina Dalman,Linnea Widman,Linnea Widman,Stefan Arver,Brian K. Lee,Cecilia Magnusson,Cecilia Magnusson,Renee M. Gardner +9 more
TL;DR: In conclusion, children of women with PCOS appear to have a higher risk of developing ASD, and exploration of potentially underlying mechanisms, including the role of sex steroids in the etiology of ASD is explored.
Journal ArticleDOI
The Genetics of Polycystic Ovary Syndrome: An Overview of Candidate Gene Systematic Reviews and Genome-Wide Association Studies.
Danielle Hiam,Alba Moreno-Asso,Helena J. Teede,Joop S.E. Laven,Nigel K. Stepto,Nigel K. Stepto,Lisa J. Moran,Melanie Gibson-Helm +7 more
TL;DR: Much work remains to identify causal variants and functional relevance of genes associated with PCOS, and to identify limitations of the current literature and important methodological considerations for future genetic studies.
Journal ArticleDOI
Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology
TL;DR: The influence of polymorphisms in important androgen related genes in governing genetic predisposition to PCOS and its related metabolic and reproductive traits is summarized.
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Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome
D. M. Liu,Laura C. Torchen,Yeon Ah Sung,Rodis Paparodis,Richard S. Legro,Stefan K.G. Grebe,Ravinder J. Singh,Robert L. Taylor,Andrea Dunaif +8 more
TL;DR: In this paper, a case-control study performed in 29 non-Hispanic white brothers of 22 women with polycystic ovarian syndrome (PCOS) and 18 control men was performed.
Journal ArticleDOI
Association between vaspin rs2236242 gene polymorphism and polycystic ovary syndrome risk.
TL;DR: The data suggest a significant association between vaspin rs2236242 polymorphism and the PCOS but this relationship is affected by obesity status.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
Nathan Mantel,William Haenszel +1 more
TL;DR: In this paper, the role and limitations of retrospective investigations of factors possibly associated with the occurrence of a disease are discussed and their relationship to forward-type studies emphasized, and examples of situations in which misleading associations could arise through the use of inappropriate control groups are presented.
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Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.