Journal ArticleDOI
Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy.
Manoj B. Mahimkar,Tanuja A. Samant,Sadhana Kannan,Jatin Tulsulkar,Prathamesh S. Pai,Devasena Anantharaman +5 more
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TLDR
GSTM1 and XPD variant alleles, independently as well as in combination may serve as important predictors of clinical outcome in radiotherapy‐treated OSCC patients.Abstract:
Polymorphisms in metabolic and DNA repair genes may alter protein function, consequently affecting patients' response to chemo/radiotherapy. We retrospectively assessed whether polymorphisms of glutathione-S-transferase genes GSTM1 (deletion), GSTT1 (deletion), GSTP1 (Ile105Val, rs1695), and DNA repair genes hOGG1 (Ser326Cys, rs1052133), XRCC1 (Arg194Trp, rs1799782, and Arg399Gln, rs25487), XPD (Asp312Asn, rs1799793, and Lys751Gln, rs13181) can predict clinical outcome in 187 oral squamous cell carcinoma patients treated with postoperative radiotherapy. The Cox proportional hazards model was used to evaluate the role of polymorphic genotypes on relapse-free (RFS) and disease-specific (DSS) survival. Deletion polymorphism of GSTM1 gene was significantly associated with DSS. The rs1799793 variant allele showed significant protection in both DSS and RFS. Significant increase in RFS but not in DSS was observed with polymorphic rs13181. The combined analysis of GSTM1 and XPD polymorphisms revealed favorable effect on survival. GSTM1 and XPD variant alleles, independently as well as in combination may serve as important predictors of clinical outcome in radiotherapy-treated OSCC patients.read more
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Cancer biomarker discovery: current status and future perspectives.
TL;DR: The emergence of powerful proteomic and genomic technologies in conjunction with advanced bioinformatic tools allows the simultaneous analysis of thousands of biological molecules that yield the discovery of new tumor signatures, which are sensitive and specific enough for early cancer detection, for monitoring disease progression and for proper treatment selection.
Journal ArticleDOI
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option
Didier Meulendijks,Luc Dewit,N B Tomasoa,H. van Tinteren,Jos H. Beijnen,Jan H.M. Schellens,Annemieke Cats +6 more
TL;DR: This study shows that capecitabine can be used as an acceptable alternative to 5-FU for the treatment of AC and shows that GSTT1 and TYMS genotypes were associated with severe (grade 3–4) toxicity.
Journal ArticleDOI
ERCC1 and ERCC2 variants predict survival in gastric cancer patients.
TL;DR: ERCC1 and ERCC2 functional SNPs may jointly affect OS in Caucasian gastric cancer patients and are associated with significantly poorer overall survival and significantly higher risk of death.
Journal ArticleDOI
DNA repair genes XPC, XPD, XRCC1, and XRCC3 are associated with risk and survival of squamous cell carcinoma of the head and neck.
TL;DR: Investigation of SNPs of the DNA repair genes XPC, XPD, XRCC1, andXRCC3 may affect risk and survival of HNSCC suggests combinations of putative risk alleles seemed to act synergistically, increasing the risk of H NSCC.
Journal ArticleDOI
Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway.
Ha-Na Oh,Ji-Hye Seo,Mee-Hyun Lee,Cheolhee Kim,Eunae Kim,Goo Yoon,Seung Sik Cho,Young Sik Cho,Hyun Woo Choi,Jung-Hyun Shim,Jung-Il Chae +10 more
TL;DR: The results demonstrated that treatment of OSCC cells with LCC induced the death receptor (DR)4 and DR5 expression level with the generation of reactive oxygen species and the upregulation of CHOP protein expression, which could provide the basis for clinical application as a new therapeutic strategy in the treatment of oral cancer.
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Journal ArticleDOI
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