Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.
TLDR
The cholesterol content of LJpoproteins and the rates of Synthesis and Catabolism have changed, as well as the composition of the Fatty Acid Composition and Upoprotein Metabolism.Abstract:
Polyunsaturated Fatty Acid Families and Interrelationships Omega-6 Fatty Acids and Plasma Lipids Plasma Cholesterol Plasma Triglycerlde Plasma LJpoprotelns and Apolipoproteins Hypolipldemic Mechanisms of Linoleic Acid Decrease in Cholesterol Absorption Increase in Fecal Steroid Excretion Reduced Cholesterol Synthesis and the Transfer of Cholesterol to the Tissues Decrease in Cholesterol Content of LJpoproteins Changes in the Rates of Synthesis and Catabolism of LJpoproteins Membrane Fatty Acid Composition and Upoprotein Metabolismread more
Citations
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The inverse relation between fish consumption and 20-year mortality from coronary heart disease.
TL;DR: It is concluded that the consumption of as little as one or two fish dishes per week may be of preventive value in relation to coronary heart disease.
Journal ArticleDOI
Importance of n−3 fatty acids in health and disease
TL;DR: The 38 articles in this supplement document the importance of n-3 fatty acids in both health and disease.
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Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review.
TL;DR: Fish oil or linolenic acid may serve as alternative sources of long-chain n-3 FAs, but further studies will be needed to document their hypolipidemic and/or antiatherogenic effects.
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Cardiovascular effects of n-3 fatty acids
Alexander Leaf,Peter C. Weber +1 more
TL;DR: Effets preventifs et benefiques sur l'atherosclerose et l'infarctus, dans l'alimentation, sur les lipides plasmatiques, sur le metabolisme and the fonctions des eicosanoides.
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Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial
TL;DR: It is concluded that there is an inverse relation between the serum cholesterol level and the risk of death from hemorrhagic stroke in middle-aged American men, but that its public health impact is overwhelmed by the positive association of higher serum cholesterol levels with death from nonhemorrhagic stroke and total cardiovascular disease.
References
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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
TL;DR: A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
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Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
TL;DR: Evidence is presented that the more unstable and major component of rabbit aorta contracting substance (RCS) formed in platelets and guinea pig lung is also thromboxane A2.
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Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis
TL;DR: Unlike arachidonic acid, eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.X.A.P.), probably because of the formation of thromboxane A3 (T.G.I3) which does not have platelet aggregating properties.
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Quantitative Effects of Dietary Fat on Serum Cholesterol in Man
TL;DR: It is shown that minimal levels of serum cholesterol were achieved with oils with an iodine number of about 100, and that more highly unsaturated oils were not more effective, which implies that monounsaturated acids are half as effective as the diene, linoleic acid, the primary polyunsaturated acid in vegetable oils.
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Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets
Mats Hamberg,Bengt Samuelsson +1 more
TL;DR: The almost exclusive transformation of the endoperoxide structure into non-prostaglandin derivatives supports the hypothesis that the end operoxides can participate directly and not by way of the classical prostaglandins in regulation of cell functions.