Journal ArticleDOI
Potent Activation of Phospholipase D by Phenylarsine Oxide in Rat Basophilic Leukemia (RBL-2H3) Cells
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TLDR
Results indicate that PKC but not tyrosine kinase may be involved in PAO-mediated PLD activation, and depletion of protein kinase C (PKC) greatly reducedPAO-stimulated PLD activity.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1994-03-15. It has received 17 citations till now. The article focuses on the topics: Tyrosine phosphorylation & Protein tyrosine phosphatase.read more
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Journal ArticleDOI
Phospholipases D1 and D2 Regulate Different Phases of Exocytosis in Mast Cells
TL;DR: It is shown by use of PLDs tagged with enhanced green fluorescent protein that PLD1, which is largely associated with secretory granules, redistributes to the plasma membrane in stimulated cells by processes reminiscent of exocytosis and fusion of granules with the plasma membranes.
Journal ArticleDOI
Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.
TL;DR: Results indicate that activation of PLC gamma 1 and protein kinase C are necessary for the stimulation of PLD by PDGF and provide no evidence for alternative mechanisms.
Journal ArticleDOI
Activation of RBL-2H3 Mast Cells Is Dependent on Tyrosine Phosphorylation of Phospholipase D2 by Fyn and Fgr
Wahn Soo Choi,Wahn Soo Choi,Takaaki Hiragun,Jun Ho Lee,Young Mi Kim,Hyoung-Pyo Kim,Ahmed Chahdi,Erk Her,Jeung Whan Han,Jeung Whan Han,Michael A. Beaven +10 more
TL;DR: The findings provide the first description of a mechanism for activation of PLD2 in a physiological setting and of a role for Fgr in FcεRI-mediated signaling.
Journal ArticleDOI
Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases.
TL;DR: Activation of PLD and secretion in a rat mast cell (RBL‐2H3) line is substantially enhanced by cholera toxin, a known activator of protein kinase (PK) A and the studies reveal interesting differences in the regulation of the translocation of granules and the fusion of these granules with the plasma membrane.
Journal ArticleDOI
Inorganic arsenite inhibits IgE receptor-mediated degranulation of mast cells.
Lee M. Hutchinson,Benett M. Trinh,Rachel K. Palmer,Christopher A. Preziosi,Jonathan H. Pelletier,Hannah M. Nelson,Julie A. Gosse +6 more
TL;DR: Data indicate that As may inhibit the ability of humans to fight off parasitic disease, by strongly inhibited Ag‐stimulated degranulation at environmentally relevant concentrations, in a manner that is very dependent on concentrations of both As and Ag.