Journal ArticleDOI
Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats
Daniela Melchiorri,Daniela Melchiorri,Russel J. Reiter,Ahmed Attia,Masayuki Hara,Alejandro Burgos,Giuseppe Nisticò +6 more
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It is suggested that melatonin confers marked protection against paraquat-induced oxidative toxicity in both the lung and liver.About:
This article is published in Life Sciences.The article was published on 1995-01-01. It has received 277 citations till now. The article focuses on the topics: Paraquat & Melatonin.read more
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Journal ArticleDOI
Melatonin as an antioxidant: under promises but over delivers.
Russel J. Reiter,Juan C. Mayo,Dun Xian Tan,Rosa M. Sainz,Moisés Alejandro Alatorre-Jiménez,Lilian Qin +5 more
TL;DR: It is the current feeling of the authors that, in view of the widely diverse beneficial functions that have been reported for melatonin, these may be merely epiphenomena of the more fundamental, yet‐to‐be identified basic action(s) of this ancient molecule.
Journal ArticleDOI
Melatonin as a natural ally against oxidative stress: a physicochemical examination
TL;DR: In this article, a review summarizes the current progress in understanding the physicochemical insights related to the free radical-scavenging activity of melatonin and concludes that melatonin efficiently protects against oxidative stress by a variety of mechanisms.
Journal Article
Heavy metal induced oxidative stress & its possible reversal by chelation therapy.
TL;DR: A comprehensive account of recent developments in the research on heavy metal poisoning particularly the role of oxidative stress/free radicals in the toxic manifestation is attempted, an update about the recent strategies for the treatment with chelating agents and a possible beneficial role of antioxidants supplementation to achieve the optimum effects are attempted.
Journal ArticleDOI
Oxidative processes and antioxidative defense mechanisms in the aging brain.
TL;DR: A newly discovered, potentially highly important antioxidant in the brain is the indole melatonin, which is more effective than glutathione in scavenging the highly toxic hydroxyl radical and also more efficient than vitamin E in neutralizing the peroxyl radical.
Journal ArticleDOI
A review of the evidence supporting melatonin's role as an antioxidant
Russel J. Reiter,Daniela Melchiorri,Ewa Sewerynek,Burkhard Poeggeler,Lorneli Barlow-Walden,Jih Ing Chuang,Genaro G. Ortiz,Darío Acuña-Castroviejo +7 more
TL;DR: Melatonin is remarkably potent in protecting against free radical damage induced by a variety of means, and DNA damage resulting from either the exposure of animals to the chemical carcinogen safrole or to ionizing radiation is markedly reduced when melatonin is co‐administered.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Book ChapterDOI
Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal
TL;DR: This chapter discusses the methods used for the qualitative and quantitative determination of aldehydes in biological systems and focuses on 4-hydroxynonenal and malondialdehyde, which are in many instances the most abundant individual aldehyde resulting from lipid peroxidation.
Journal ArticleDOI
Melatonin : a peroxyl radical scavenger more effective than vitamin e
TL;DR: Melatonin, which is a lipid-soluble compound, was twice more active than vitamin E, believed to be the most effective lipophilic antioxidant.
Journal ArticleDOI
Paraquat: model for oxidant-initiated toxicity.
James S. Bus,James E. Gibson +1 more
TL;DR: Paraquat-induced pulmonary toxicity is a potentially useful model for evaluation of oxidant mechanisms of toxicity and characterization of the consequences of intracellular redox cycling of xenobiotics will no doubt provide basic information regarding the role of this phenomena in the development of chemical toxicity.